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A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy
Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…
Breast cancer risk prediction technology using genomic classifier
Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…
A smartphone-based detector for mobile health applications
Unmet Need It is estimated that there are over 6 billion smartphone users worldwide, which translates to almost 83% of the world’s population. Due to their widespread use, smartphones present a golden opportunity to redefine…
Genomic Biomarkers of Locally Advanced Breast Cancer (LABC) and Inflammatory Breast Cancer (IBC)
Unmet Need Locally advanced breast cancer (LABC) and inflammatory breast cancer (IBC) are associated with high 5-year mortality rates (respectively 55% and 33%), especially when compared to early-stage breast cancers (~80%). LABC and IBC are…
A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy
Unmet Need Non-small-cell lung cancer accounts for 82% of all lung cancer diagnoses. Immune checkpoint blockade treatment is an exciting new course of action among advanced stage non-small-cell lung cancer patients. However, only a minority…
Detecting and predicting progression of osteoarthritis by biomarker analysis
Unmet Need Osteoarthritis (OA) is a prevalent chronic disease that impacts 32.5 million US adults and hundreds of millions worldwide. Further, global incidence of OA is increasing due to rises in geriatric populations and other…
Parametrization of fractal signature data
The risk of knee osteoarthritis progression can be predicted from the subtle characteristics revealed on a knee radiograph of the subchondral bone, i.e. bone that underlies the articular cartilage. This technology is software code to…
HIV-1 incidence biomarkers
Background Measures of HIV incidence are used to help public health officials, researchers, and policy makers monitor the epidemic, evaluate the impact of interventions, and assist in the identification of sites for HIV prevention trials.…
Wearable device for early detection of influenza and common cold
Unmet Need Approximately 10% of the US population is infected with influenza each year resulting in 3 to 5 million severe cases and up to 500,000 deaths. Early detection of influenza-like illness can limit the…
A quality control tool for multi-energy X-ray computed tomography imaging
Unmet Need X-ray computed tomography (CT) imaging devices are ubiquitous in any radiology department and CT examinations are among the most commonly ordered diagnostic procedure. Multi-energy computed tomography is an emerging imaging technology that is…
Machine learning algorithm to predict malignancy in thyroid nodules
Value Proposition An estimated 10% of the general population in the United States are expected to develop a thyroid nodule in their lifetime. Although the vast majority of thyroid nodules are noncancerous, a small proportion…
Novel diagnostic method for aspergillus Infection
Unmet Need Invasive aspergillosis (IA) is a major cause of critical illness in immunocompromised patients. IA is caused by Aspergillus, a type of fungal mold, and it usually affects the host’s pulmonary structure. While most…