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Non-invasive peripheral retinal scanner using OCT

Non-invasive peripheral retinal scanner using OCT

Unmet Need Images and light that sporadically appear in an individual’s visual field are known as “Flashes and floaters.” These optical aberrations bring approximately 150,000 patients in for eye exams each year in the United…

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Metabolite biomarkers of human heart failure

Metabolite biomarkers of human heart failure

Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…

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Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…

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Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…

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New small molecules targeting castration-resistant prostate cancer

New small molecules targeting castration-resistant prostate cancer

Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…

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Gene expression assay to determine radiation exposure

Gene expression assay to determine radiation exposure

Unmet Need Ionizing radiation poses a significant risk as an environmental hazard and is linked to the development of multiple cancers in adults and children. Healthcare professionals, nuclear power plant employees, and research scientists are…

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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…

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Multiscale coherence imaging for assessing epithelial tissue health in precancerous detection

Multiscale coherence imaging for assessing epithelial tissue health in precancerous detection

Unmet Need Epithelial cells act as the body’s first line of defense against foreign elements and are constantly being replaced by newly grown cells. Due in part to these factors, 90% of all cancers originate…

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Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness

Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness

Unmet Need It is estimated that surgical complications arise in 16.4%, or almost 1 in 6 surgical procedures in the United States. Most complications have an immunological basis related to infection or aberrant adaptation to…

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Structural variants of TERT in brain tumors

Structural variants of TERT in brain tumors

Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…

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A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure

A humanized pro-N-cadherin antibody that can be used for treating and predicting heart failure

Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…

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A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy

Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…

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