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TRPV4 ion channels as a target in systemic pruritic diseases

TRPV4 ion channels as a target in systemic pruritic diseases

Unmet Need Pruritus, or an itching sensation, is one common symptom shared by hepatobiliary diseases, intrahepatic cholestasis of pregnancy (between 0.2% of 2% of all pregnancies) chronic kidney disease (55% prevalence globally), and pruritic psoriasis.…

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Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy

Targeted delivery of gene therapy for cardiac reprogramming with enhanced efficacy

Unmet Need Cardiac injury results in irreversible and permanent loss of cardiomyocytes, leading to heart failure with ~40% mortality within 4 years from diagnosis. It has been shown that directly reprogramming scar fibroblasts into new…

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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…

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A microscopy method for acquiring polarization-sensitive phase information in 3D

A microscopy method for acquiring polarization-sensitive phase information in 3D

Unmet Need The majority of biological research and clinical diagnostics has involved the use of optical imaging systems for transparent specimens that rely on scalar properties like phase contrast. These systems have proved useful for…

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Schenk Composer: A framework for algorithmic music generation

Schenk Composer: A framework for algorithmic music generation

Unmet Need As artificial intelligence (AI) and machine learning become more commonplace in modern society, there is increasing demand for these tools to be incorporated in creative applications that normally rely completely on human intuition.…

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A steerable and adjustable shock wave generator for kidney stone treatment

A steerable and adjustable shock wave generator for kidney stone treatment

Unmet Need Lithotripsy is a non-invasive procedure used to break down kidney stones too big to pass through the urethra. This relies on electromagnetic or electrohydraulic waves passed from a tabletop machine through a patient’s…

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Ultra-wideband transparent conductive electrode for solar and radiation heat management

Ultra-wideband transparent conductive electrode for solar and radiation heat management

Unmet Need In the United States, 37% of electricity consumption is attributable to residential use with a sizeable portion of that electricity going towards heating and cooling applications (15% of national energy consumption goes towards…

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Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes

Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes

Unmet Need Adoptive cell therapy (ACT), also known as cellular immunotherapy, leverages immune cells to fight cancer. Examples include chimeric antigen receptor T-cell (CAR-T) therapy, engineered T-cell receptor (TCR) therapy, and tumor-infiltrating lymphocyte (TIL) therapy.…

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Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma

Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma

Unmet Need Chimeric Antigen Receptor (CAR) T-cell therapy, a form of immunotherapy, has proven highly effective against blood cancers such as leukemias and lymphomas. This therapy uses T-cells that are genetically engineering ex vivo to…

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Adoptive T-cell immunotherapy to treat cancer caused by Epstein-Barr virus

Adoptive T-cell immunotherapy to treat cancer caused by Epstein-Barr virus

Unmet Need Epstein-Barr virus (EBV) is an infectious disease that has been shown to cause a number of cancers originating from EBV-afflicted cells. Across the globe, EBV is associated with approximately 200,000 cases of malignancies…

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EEG-based monitoring of brain recovery following stroke

EEG-based monitoring of brain recovery following stroke

Unmet Need Stroke is the third leading cause of disability in the US, affecting 800,000 annually. Stroke occurs when blood supply to the brain is impeded, leading to brain damage. Currently, recovery from stroke is…

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Therapy for neurotensin positive cancers

Therapy for neurotensin positive cancers

Unmet Need Under normal conditions, neurotensin signaling is largely constrained to the nervous system. However, abnormal expression is seen in cancers that are aggressive or have a poor prognosis such as pancreatic, which has a12.5%…

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