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iPSC line to identify novel therapies for ARVC
Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…
Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
Hamster a1B-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
A mouse strain lacking functional GRK4 gene
GRK4 is prominently expressed in testes, with expression also in select brain regions (cerebellum) and other organs and cell types. GRK4 has been implicated in regulation of cerebellar mGluRl and GABA, receptors, and may be…
Conditional microRNA-9 inhibitor and reporter mouse
Technology Duke inventors have created a novel mouse model termed the conditional microRNA-9 inhibitor and reporter mouse that shows the level of microRNA-9 in all tissues and demonstrates a microRNA-9 deficiency phenoptype. When bred with…
ZIP fish: zebrafish insulin promoter
Duke scientists have created stable transgenic zebrafish with strict pancreatic, beta cell-specific expression of GFP in embryos, larvae and adult. This model can serve as a high throughput screen for diabetic drugs.
Rat a1A-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
Activated caspase-3 reporter mouse
Technology The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and…
Transgenic zebrafish with hand2 tagged with GFP
Technology Duke inventors have generated transgenic zebrafish with the native hand2 developmental transcription factor tagged with green fluorescent protein (GFP). This allows visualization of the activation of hand2 regulatory sequences and can be used for…
Dopamine transporter knockout mice as a screening tool for anti-parkinsonian and anti-dyskinetic agents
Unmet Need The dopamine precursor L-DOPA is the primary treatment for Parkinson's Disease (PD). However, in addition to alleviating motor deficits associated with PD, 50-90% of patients experience side effects such as dyskinesia after 5-10…
An induced pluripotent stem cell model of Duchenne muscular dystrophy
Unmet Need Duchenne muscular dystrophy (DMD) is a rare genetic disease that causes the skeletal and heart muscles to weaken. Due to a mutation in dystrophin, an important protein involved in muscle structure, individuals with…
Cell line expressing chimeric Tie2 receptors
Technology Duke inventors have generated a cell line that expresses chimeric Tie2 receptors. Specifically, NIH 3T3 cells were infected with retroviruses containing a plasmid that encoded the extracellular and transmembrain domains of the c-fms receptor…