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Method of growing and analyzing single cells within microfluidic droplets
Unmet Need The importance and influence of the microbiome on human health is becoming increasingly recognized, with the human microbiome linked to processes varying widely across the body. Accumulating data suggests that the microbiome plays…
A CRISPR-based system for modifying the length of 3’ untranslated regions (3’UTR) of an mRNA transcript that offers novel treatment strategies for prostate cancer and other diseases
Unmet Need Abnormal length changes in the 3’ untranslated region (3’UTR) of mRNAs are associated with many diseases such as systemic lupus erythematosus, α-thalassemia, facioscapulohumeral muscular dystrophy, and cancer. While existing technologies can manipulate expression…
Harvis: an interactive virtual reality tool for modification and simulation of blood flow
Unmet Need Cardiovascular disease (CVD) is the largest underlying cause of mortality in the United States, causing one in every three deaths and costing an estimated $316 billion dollars a year. In recent years, computational…
A system for screening compounds that alter smell perception
Unmet Need Olfactory sensation profoundly influences a person’s quality of life. In addition to the aesthetic aspects of life associated with olfactory sensation, approximately 2 million Americans experience some type of olfactory dysfunction. Studies show…
Software for predicting vibrational blade response in gas turbines
Unmet Need Virtually all commercial aircraft use gas turbine engines and 90 percent of the world’s electricity is produced by turbines. One of the grand challenges in turbomachinery is to predict the vibratory response of…
Screening method to identify lead compounds to treat hereditary neurological disorders and other diseases associated with MutSβ activity
Unmet Need The human genome is constantly under the threat of DNA damage and replication errors that can result in mutations. A heterodimer of DNA mismatch repair proteins named MutSβ has been linked to a…
A technique that promotes the stringent control of gene expression within specific cell types
Unmet Need A major challenge of gene therapy is to target only the intended cell- and/or tissue-type. For this reason, many gene therapies are delivered using adeno-associated virus (AAV) vectors with gene-specific promoters; however, off-target…
A method for identifying sour-taste receptor ligands as well as compounds that modulate their activity
Unmet Need The taste system is essential for feeding and survival as it helps humans evaluate the nutritional content in food. Every year, taste and smell dysfunctions affect more than 200,000 people, including those undergoing…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
Fluorescence-based high-throughput assay for identifying antivirals to control COVID-19 pandemic
Unmet Need Current efforts to control COVID-19 are largely focused on behavioral modifications such as social distancing and the use of masks. These approaches attempt to slow the spread of the virus, but meaningful control…
Isogenic HCT116 cell lines with heterozygous or homozygous IDH1R132H mutation
Value Proposition One of the major challenges in studying the implications of the IDH1 mutations has been the dearth of cell line models which recapitulate IDH mutation-dependent tumor progression. Technology Researchers at Duke have generated…
Optical device for in vivo assessment of tissues
Value Proposition Fluorescence and diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum are increasingly being investigated for tissue characterization. These biological scatterers, absorbers, and fluorophores may be used to indicate the existence of certain diseases.…