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Identification and application of novel lipoglycodepsipeptide antibiotics

Identification and application of novel lipoglycodepsipeptide antibiotics

Unmet Need Antibiotic resistance (ABR) is a global public health concern. In 2019, an estimated five million deaths were attributed to antibiotic resistant pathogens. A recent study estimates that ABR could cause nearly ten million…

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MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients

MEWS: a clinical model to predict probability of maternal sepsis trigger in obstetrics patients

Unmet Need Sepsis is a life-threatening emergency characterized by an overactive and improper inflammatory response by the body to an infection or injury leading to tissue damage, organ failure and death if not treated promptly.…

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LpxH targeting antibiotics for Gram-negative bacteria

LpxH targeting antibiotics for Gram-negative bacteria

Unmet Need Antimicrobial resistance of bacteria to antibiotics is a major threat to public health. In 2019, 4.95 million deaths, 64% of all bacterial infection related deaths globally, were attributed to antimicrobial resistance to antibiotics.…

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HIV treatment and prevention using broadly neutralizing antibodies

HIV treatment and prevention using broadly neutralizing antibodies

Unmet Need For over 40 years, the human immunodeficiency virus (HIV) pandemic has affected the quality of life and decreased the life expectancy for millions of people with approximately 1.5 million new cases each year.…

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Smart microscope for diagnosing disease

Smart microscope for diagnosing disease

Value Proposition Since its invention, the microscope has been optimized for interpretation by a human observer. Recently, however, deep learning algorithms have been developed for automated image analysis in a variety of important contexts, such…

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CRISPR-based antiviral treatment of coronavirus infections

CRISPR-based antiviral treatment of coronavirus infections

Unmet Need The global market for antiviral drugs is a large one, topping $60B, and is getting larger due to the ongoing COVID-19 pandemic. Spurred on by a $3B investment from the U.S. government into…

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Wearable device for early detection of influenza and common cold

Wearable device for early detection of influenza and common cold

Unmet Need Approximately 10% of the US population is infected with influenza each year resulting in 3 to 5 million severe cases and up to 500,000 deaths. Early detection of influenza-like illness can limit the…

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Novel diagnostic method for aspergillus Infection

Novel diagnostic method for aspergillus Infection

Unmet Need Invasive aspergillosis (IA) is a major cause of critical illness in immunocompromised patients. IA is caused by Aspergillus, a type of fungal mold, and it usually affects the host’s pulmonary structure. While most…

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Small molecules that target RNA structures within the CoV genome

Small molecules that target RNA structures within the CoV genome

Unmet Need SARS-CoV-2 is the etiological agent of the COVID-19 respiratory disease, the largest scale respiratory virus pandemic the world has witnessed since the 1918 Spanish flu and that has claimed more than 1.4 million…

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Platform for generating a seasonal vaccine for both influenza and coronaviruses

Platform for generating a seasonal vaccine for both influenza and coronaviruses

Unmet Need Similar to the flu vaccine, the need for seasonal post-immunization boosting to offer protection following COVID-19 vaccines remains possible. However, more than 8 percent of people who received a first dose of Pfizer…

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A method for treating pain and inflammation using GPR37 agonists

A method for treating pain and inflammation using GPR37 agonists

Unmet Need Uncontrolled inflammation is a prominent component of many common diseases and is the root cause of chronic pain. When inflammation persists, the inflammatory factors are never completely cleared from the system, leading to…

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Synthetic peptide adjuvants for mucosally-administered vaccines

Synthetic peptide adjuvants for mucosally-administered vaccines

Provided herein are peptides that have activity as mast cell activating proteins (MCAP), as well as compositions, adjuvant compositions, vaccines, and pharmaceutical formulations that include the peptides. Also provided are methods of using the peptides,…

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