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Intubation tent to protect healthcare workers from infected patients

Intubation tent to protect healthcare workers from infected patients

Value Proposition Under the current COVID crisis, health care workers need protection against respiratory infections transmitted by patients undergoing treatment. Patients undergoing intubation for surgery or prior to being placed on a ventilator can expose…

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Strengthening a patient’s immune functions to prevent infectious diseases without developing antibiotic resistance

Strengthening a patient’s immune functions to prevent infectious diseases without developing antibiotic resistance

Unmet Need Despite the development of numerous antibiotics over the years, the arms race between humans and emergent antibiotic-resistant microbes remains. More than 2.8 million antibiotic-resistant infections and 35,000 deaths occur in the U.S. each…

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Novel small molecule mast cell activator vaccine adjuvants

Novel small molecule mast cell activator vaccine adjuvants

Value Proposition Mast cells (MCs) are innate immune cells highly prevalent in the dermal region of the skin and in the respiratory, gastrointestinal, and urinary tract mucosa. The strategic location at the host–environment interface and…

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Molecular diagnostic test for acute respiratory viral infections

Molecular diagnostic test for acute respiratory viral infections

Unmet Need Acute respiratory viral (ARV) infections are among the most common reasons for patient visits in primary and acute care settings. ARV can be caused by many viruses including human rhinovirus (HRV), respiratory syncytial…

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Novel class of antibiotics effective against drug-resistant bacteria

Novel class of antibiotics effective against drug-resistant bacteria

Unmet Need Antimicrobial resistance among Gram-negative bacilli is increasing and becoming alarmingly common, especially as bacterial strains become resistant to multiple antibiotics. The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. There…

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Structural analogues of N-pyridin-4-yl-1,3-benzothiazole-6-carboxamide as lead compounds for preventing or treating urinary tract infections

Structural analogues of N-pyridin-4-yl-1,3-benzothiazole-6-carboxamide as lead compounds for preventing or treating urinary tract infections

Value Proposition Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs). Over 100 million UTIs occur annually throughout the world, including more than 7 million cases in U.S. adolescents and…

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Structural analogues of 3- [(2,6-difluorobenzoyl)amino]-5-(4-ethoxyphenyl)thiophene-2-carboxylic acid as lead compounds for preventing or treating urinary tract infections

Structural analogues of 3- [(2,6-difluorobenzoyl)amino]-5-(4-ethoxyphenyl)thiophene-2-carboxylic acid as lead compounds for preventing or treating urinary tract infections

Value Proposition Uropathogenic Escherichia coli (UPEC) is the leading cause of community-acquired urinary tract infections (UTIs). Over 100 million UTIs occur annually throughout the world, including more than 7 million cases in U.S. adolescents and…

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Inactivating viral replication with CRISPR/Cas systems

Inactivating viral replication with CRISPR/Cas systems

Value Proposition Current gene therapy approaches based upon targeted DNA endoculeases, such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), are based upon custom built DNA binding domains. Although gene therapy with…

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Device for personalizing ventilation settings on a shared system

Device for personalizing ventilation settings on a shared system

Value Proposition In times of emergency, multiple patients might require to be supported on the same ventilator system. However, patients might have different degrees of lung function, including lung compliance and required volumes of support.…

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A therapeutic vaccine platform for treating influenza viruses

A therapeutic vaccine platform for treating influenza viruses

Value Proposition Influenza virus infections represent a substantial global burden on human health. Each year, it is estimated that influenza viruses cause up to 5 million severe infections globally, resulting in up to 645,000 mortalities.…

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Mast cell targeting to predict and prevent virus-induced vascular leakage

Mast cell targeting to predict and prevent virus-induced vascular leakage

Value Proposition Dengue is a mosquito spread virus that affects millions of people worldwide. According to the World Health Organization, there are approximately 390 million dengue virus infections each year, and it is the leading…

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Replication competent bi- and tri-valent influenza viruses as vaccines

Replication competent bi- and tri-valent influenza viruses as vaccines

Value Proposition Influenza infection is a major public health concern, with an estimated 200,000 Americans hospitalized each year with flu or flu-related illness. The most effective method for flu prevention is vaccination, however, due to…

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