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Application of non-enzymatic posttranslational protein modifications as biomarkers of musculoskeletal disease
Duke University is seeking a company interested in commercializing novel biomarkers of musculoskeletal disease and a novel strategy enhancing the effectiveness of such biomarkers. Musculoskeletal diseases include a multitude of disorders that are prevalent in…
A murine model for autoimmune hepatitis, liver inflammation, and fibrosis
Duke University is seeking a company interested in licensing a new mouse model of autoimmune hepatitis. This mouse model exhibits the hallmarks of the human disease and may serve as an excellent model system for…
Norepinephrine transporter Knockout Mice
Duke University is seeking a company interested in commercializing a novel and versatile animal model of anti-depressant-related patients. Depression is the fourth leading contributor of disease worldwide with 18.8 million adult sufferers in the United…
A novel target for therapeutic intervention of muscle atrophy
The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are…
Test of Verbal Expression and Reasoning (TOVER)
The TOVER is non-standardized assessment of expressive language in context and verbal reasoning. The 64 item test was specifically designed to assess language function in children and adults with Down syndrome across a broad range…
Viral microRNAs expressed in cells latently infected with Herpes Simplex Virus Type 1
The present invention relates, in general, to micro RN As and, in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit such microRNAs…
Neuroprotection by small molecule EphB3 kinase inhibitors
EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such…
4D Rat Whole Body (ROBY) Phantom Version 2.0
The 4D ROBY and MOBY phantoms were developed for small animal imaging research. They include highly detailed anatomies for a laboratory rat (ROBY) or mouse (MOBY) with over 1400 defined structures. The phantoms were designed…
4D Mouse Whole Body (MOBY) Phantom Version 2.0
The 4D ROBY and MOBY phantoms were developed for small animal imaging research. They include highly detailed anatomies for a laboratory rat (ROBY) or mouse (MOBY) with over 1400 defined structures. The phantoms were designed…
4D Extended Cardiac-Torso (XCAT) Phantom Version 2.0
The 4D XCAT phantom was developed to provide virtual patients for medical imaging research. The XCAT software includes a pair of highly detailed male and female anatomies for subjects that are 50th percentile in terms…
CD3/CD28 costimuled and expanded cord blood T lymphocytes can be primed by killed leukemic cells to generate cytotoxic lymphocytes (CTL) available for adoptive immunotherapy against leukemia
Value Proposition Allogenic hematopoietic cell transplant (bone marrow or stem cell transplantation) is a therapy method used on hematology-related cancers and various autoimmune diseases. This therapy method has proven to be widely successful and one…
Targeting hyaluronan, CD44 and lung fibroblast invasion to block fibrogenesis
Value Proposition Idiopathic pulmonary fibrosis (IPF) is the most common type of pulmonary fibrosis. Scarring causes stiffness in the lungs and makes it difficult to breathe. Currently, more than 80,000 adults in the United States…