A novel target for therapeutic intervention of muscle atrophy

The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositions for treating muscle atrophy and/or inflammation by inhibiting HDAC4 activity.

Duke File (IDF) Number



  • Yao, Tso-Pang
  • Barrientos De Renshaw, Tomasa
  • Cohen, Todd

For more information please contact


School of Medicine (SOM)