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Showing 20 matches for the following: Inventor: "Caron, Marc G" ×
Therapy for neurotensin positive cancers
Unmet Need Under normal conditions, neurotensin signaling is largely constrained to the nervous system. However, abnormal expression is seen in cancers that are aggressive or have a poor prognosis such as pancreatic, which has a12.5%…
Hamster a1B-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
Conditional microRNA-9 inhibitor and reporter mouse
Technology Duke inventors have created a novel mouse model termed the conditional microRNA-9 inhibitor and reporter mouse that shows the level of microRNA-9 in all tissues and demonstrates a microRNA-9 deficiency phenoptype. When bred with…
Rat a1A-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
Activated caspase-3 reporter mouse
Technology The activated caspase-3 reporter mouse is an in vivo screening assay for apoptosis (regulated, energy-dependent cell death) in all tissues. Fluorescence miscroscopy of the fluorophore mCerulean reveals levels of caspase-3 activation in cells, and…
Dopamine transporter knockout mice as a screening tool for anti-parkinsonian and anti-dyskinetic agents
Unmet Need The dopamine precursor L-DOPA is the primary treatment for Parkinson's Disease (PD). However, in addition to alleviating motor deficits associated with PD, 50-90% of patients experience side effects such as dyskinesia after 5-10…
Human B2-adrenergic receptor CHW cell line
Technology Duke inventors have generated a chinese hamster fibroblast cell line that expresses the human β2–adrenegic receptor.
Transgenic mouse strains to investigate biased ghrelin receptor (GHSR1a) drug candidates
Technology Duke inventors have created five novel transgenic mice with point, knockout, or humanizing mutations to the ghrelin receptor (GHSR1a): G protein-biased GHSR1a mouse (GHSR-P147A): CRISPR-Cas9 RNA-induced homology-directed repair (HDR) was used to create a…
VMAT2 heterozygous mouse line as a model of brain dysfunction associated with behavioral deficits
Technology Duke inventors have developed a novel mouse model that is heterozygous for vesicular monoamine transport 2 (VMAT2), a protein located in the central nervous system that transports monoamines such as dopamine and serotonin from…
A functionally selective ghrelin receptor (GHSR) ligand for treatment of chemical and food addiction
Unmet Need The number of Americans with addiction-related disorders, including substance use disorders (SUD) and food addiction is increasing rapidly each year. Recent estimates indicate that >20 million people in the U.S. have been diagnosed…
Non-opioid treatment for chronic pain using a neurotensin receptor 1 modulator
Unmet Need For individuals experiencing chronic pain, day-to-day tasks and activities can become difficult or impossible. It can also lead to other long-term health challenges including insomnia, stress, anxiety, and depression. Chronic pain is so…
System for detecting three protein-protein interactions in living cells
Unmet Need Recognizing Protein-Protein Interactions (PPIs) is central to many molecular biology studies aiming to identify important targets for the development of therapeutic drugs. There are thousands of PPIs that are essential to understand the…