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Method for immune tolerance induction in patients receiving enzyme replacement therapy for a variety of metabolic disorders
Unmet Need Genetically based metabolic disorders affect 1 in 2500 births globally and many of these disorders result in an enzyme deficiency. In most cases, a single enzyme is not produced by the body at…
Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Functionalized microfiber mesh for inflammation and thrombosis prevention
Unmet Need Trauma is a significant global health issue responsible for approximately 10% of deaths and over 15% of disabilities worldwide according to the World Health Organization. In addition to physical injuries, trauma-induced inflammation plays…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
Universal Antibodies Effective Against Both Influenza A and B
Unmet Need Distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing significant widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could protect against…
Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients
Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…
RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment
Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…
Leukocyte phenotyping methods to provide prognostic information and risk/resilience stratification for surgical procedures and critical illness
Unmet Need It is estimated that surgical complications arise in 16.4%, or almost 1 in 6 surgical procedures in the United States. Most complications have an immunological basis related to infection or aberrant adaptation to…
A novel T-cell-based immunotherapy for brain cancer
Unmet Need Cancer immunotherapy represents a new paradigm in cancer treatment with the goal of harnessing the immune system to selectively attack a patient’s tumor. T-cell-based immunotherapies encompass chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes,…
A tool to facilitate high affinity binding between beta-Arrestin and GPCR
Unmet Need Beta-arrestins are a highly conserved family of cytosolic adaptor proteins that contribute to a multitude of physiological functions through a canonical interaction with various G protein-coupled receptors (GPCRs). Through agonist binding to GPCRs,…
Topical MEK inhibition as a new modality for inflammatory skin diseases and cancers
Unmet Need Inflammatory skin conditions affect many people, with a wide range of severities. Common skin disorders, such as psoriasis and atopic dermatitis, affect close to 20% of the population. Skin lesions associated with bone…
A genomics-based method to identify cancer patients that will benefit from immune checkpoint therapy
Unmet Need Non-small-cell lung cancer accounts for 82% of all lung cancer diagnoses. Immune checkpoint blockade treatment is an exciting new course of action among advanced stage non-small-cell lung cancer patients. However, only a minority…