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3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
Systems and methods for predicting real-time behavioral risks using everyday images
Unmet Need Daily environments can significantly impact health outcomes, influencing factors such as stress, sleep, nutrition, and harmful behaviors. Fall risk is a major concern, particularly for older adults, with environmental factors like poor lighting…
Radiation Treatment Planning Software with Integrated Computer Aided Tumor Detection
Unmet Need Radiation is an effective component of cancer therapeutics and is utilized in approximately 50% of all cancer cases. For treatment to be effective, a treatment plan must be created that takes into consideration…
Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Alternating Hemiplegia of Childhood (AHC) is a rare neurologic disorder affecting children, causing episodes of temporary paralysis, dystonia, and severe behavioral issues, with prevalence estimates ranging from 1 in 1 million to 1…
Precision Gene Therapy for Parkinson’s Disease: Targeted SNCA Down-regulation in Dopaminergic Neurons
Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting approximately 10 million people globally and 1 million in the U.S. PD is characterized by involuntary movements such as tremors, stiffness, and…
Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
An automated system for dermatological laser surgery
Value Proposition Laser-based devices show promise for highly effective treatment of a range of cutaneous applications, including skin rejuvenation, tattoo removal, hair removal, vascular and pigmented lesions, and even skin cancers. During these procedures, a…
Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming
Unmet Need Every year, close to 1 million Americans experience a heart attack. A heart attack results in the loss of specialized cells called cardiomyocytes, which are crucial for the heart’s contraction and rhythmic beating.…
FK506/FK520 analogs modified to increase fungal specificity and reduce immunosuppression
Unmet Need Fungal infections are becoming increasingly prevalent worldwide, with 150 million cases and 1.7 million fatalities reported in the last year alone. The challenge in treating these infections stems from the rise of multi-drug-resistant…
Novel RNA-based anti-cancer therapeutic for sustained immunotherapy by combined pattern recognition receptor (PRR) activation and anti-microRNA therapy (AMT)
Unmet Need Cancer is incredibly prevalent and current therapies are insufficient. Globally, lifetime prevalence is 1 in 5, and mortality is 1 in 9 in men and 1 in 12 in women. Solid tumors account…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…