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The Air-X Syringe: using airway loss of resistance for safer cricothyroidotomies
Unmet Need Between 13-20 million tracheal intubations are performed in the US each year, including surgical and emergency intubations. When the upper airway is obstructed, a needle cricothyroidotomy can be used to insert a catheter…
Elastomer films with strain-induced color change to detect functional failures
Unmet Need Elastomers are polymer materials that can recover their original shape after being deformed. These materials, such as rubber or some plastics, are widely used in industrial and commercial applications in the automobile and…
Functionalized microfiber mesh for inflammation and thrombosis prevention
Unmet Need Trauma is a significant global health issue responsible for approximately 10% of deaths and over 15% of disabilities worldwide according to the World Health Organization. In addition to physical injuries, trauma-induced inflammation plays…
An organ chip model of the mammalian joint
Unmet Need Human movement relies on the function of cartilage-containing joints. In conditions such as osteoarthritis (OA), the cartilage within the joints becomes inflamed and degrades, leading to intense debilitating pain when bending joints. Despite…
Spine Secure’s Non-Invasive Halo
Unmet Need Globally, over 15 million people are living with spinal cord injury as of 2021. Based on data from 2019, 0.9 million new cases emerged in a year. While most cases are due to…
Novel necroptosis inhibitor for treating inflammatory diseases
Unmet Need Necroptosis is a form of cell death characterized by the rapid loss of plasma membrane integrity, leading to the activation of the immune system and subsequent inflammation. This process has been implicated in…
MEAPS: A method to discover bioactive compounds generated by gut microbes
Unmet Need Microbial communities play important roles in environmental, animal, and human health. In humans, beneficial bacteria living within the intestinal tract can promote gut development, balance immunity, and enhance nutrient metabolism. Alternatively, colonization with…
Serum- and stroma-free chemically defined system for lung stem cell expansion and differentiation
Unmet Need Cell culture, ex vivo growth of cells under controlled conditions, is a fundamental technique in biomedical research for studying disease mechanisms and developing new therapies. The traditional 2D environments used for cell culture,…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
Gene signature-based screening tool for Castration Resistant Prostate Cancer
Unmet Need Prostate cancer is the second most common type of cancer diagnosed among adult males, with the first line of treatment being androgen deprivation therapy (ADT). However, up to 20% of patients develop a…
Rapid, responsive, and active dissection insertion device for large-bore chest tubes
Unmet Need Tube Thoracostomy, a critical procedure for removing fluids and air from around the lungs and heart, has a high complication rate of 20% due to the technical skill required and anatomical differences between…
Lightweight, portable wearable device for passive hand and wrist rehabilitation with adjustable therapy settings
Unmet Need Stroke, a prevalent cerebrovascular disease affecting 7.8 million patients in the US, often leaves survivors with hemiparesis, impacting the upper extremity on one side. About 85% of stroke patients experience reduced hand motor…