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Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development

Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…

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Structural variants of TERT in brain tumors

Structural variants of TERT in brain tumors

Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…

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Anesthesiology Resource Management System (ARMS), an AI software to predict and plan resource utilization

Anesthesiology Resource Management System (ARMS), an AI software to predict and plan resource utilization

Unmet Need Surgery makes up a majority of both the costs and revenue for major hospitals, with operating rooms accounting for 40% of an average hospital’s annual budget. Human resources, especially in anesthesia, are among…

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Gene therapy for long-term treatment of GSDIa

Gene therapy for long-term treatment of GSDIa

Unmet Need Glycogen storage disease type Ia (GSDIa), or von Gierke disease, is a rare heritable metabolic disorder that impacts the liver and kidneys due to an inability to break down glycogen. An estimated 1…

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The ubiquitination status of the glucagon receptor determines signal bias

The ubiquitination status of the glucagon receptor determines signal bias

Unmet Need Currently, management of diabetes and other metabolic disorders lacks understanding of how the ubiquitination status of the glucagon receptor (GCGR) impacts its signaling pathways. Conventional approaches in targeting G protein-coupled receptors (GPCRs) for…

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Method to enable cancer immune checkpoint therapy

Method to enable cancer immune checkpoint therapy

Unmet Need Cancer remains to be a heavy burden on Americans as many current gold-standard treatments can be ineffective. In 2022, an estimated 623,000 Americans were living with metastatic cancer and is predicted to increase…

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Gene therapy for long-term treatment of Pompe disease

Gene therapy for long-term treatment of Pompe disease

Unmet Need Pompe disease is a rare heritable disorder impacting heart and skeletal muscle function with an estimated incidence rate of 1 in 40,000 births in the US. Of these affected births, a third take…

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Novel factor VIIa chimeras for safer hemostasis

Novel factor VIIa chimeras for safer hemostasis

Unmet Need Chronic wounds impact 6.5 million patients in the US, leading to complications such as infections, hemorrhage, gangrene, and amputations. The resulting health burden costs the US healthcare system an estimated $25 billion annually…

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Reagentless biosensors to detect multiple analytes

Reagentless biosensors to detect multiple analytes

Unmet Need Although biosensors are in widespread use to detect and report analytes, such as the level of nutrients in food and beverage samples, blood glucose in patients, and contamination in water samples, many suffer…

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A semiconducting material that switches between glass and crystalline states at lower temperatures than conventional inorganic semiconductors

A semiconducting material that switches between glass and crystalline states at lower temperatures than conventional inorganic semiconductors

Unmet Need In recent times, different forms of inorganic glasses have emerged that are distinct from what human civilization has been using for more than 5,000 years. Due to the advent of such glasses, a…

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A novel T-cell-based immunotherapy for brain cancer

A novel T-cell-based immunotherapy for brain cancer

Unmet Need Cancer immunotherapy represents a new paradigm in cancer treatment with the goal of harnessing the immune system to selectively attack a patient’s tumor. T-cell-based immunotherapies encompass chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes,…

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WireCleat – Fully safe Seldinger Technique device for prevention of guide wire retention

WireCleat – Fully safe Seldinger Technique device for prevention of guide wire retention

Unmet Need Catheters are widely used in many medical disciplines as a means of gaining easy access to internal body cavities like blood vessels or hollow organs. The Seldinger technique is a common method for…

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