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Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation
Unmet Need Precise and selective manipulation of microscale particles and cells in liquid suspension (colloidal mixture) is a challenge in the fields of biomedicine and materials science. Current methods for the assembly of colloidal matter…
Toolkit to edit any gene with universal CRISPR/Cas9 vectors
Unmet Need Genetic editing with the CRISPR/Cas9 system has quickly become ubiquitous in biotechnology research. One common application is studying proteins by editing the genes that encode them. Proteins have numerous functions, acting as receptors,…
Gene expression signature to predict sepsis mortality
Unmet Need Sepsis is responsible for half of the in-hospital deaths in the US. It is characterized by organ dysfunction resulting from an uncontrolled response to an infection. The standard treatment for sepsis includes source…
Molecular Classifiers of Bacterial Infection
Unmet Need Bacterial infections can lead to various outcomes, with septicemia posing significant morbidity and mortality risks for patients. Septicemia occurs when bacteria enter and spread through the bloodstream, triggering an extreme immune response in…
Vectorial Fourier ptychography for high-resolution widefield polarization imaging in pathology and research
Unmet Need In the United States, over 10,000 diagnostic imaging centers rely on microscopy for diagnostics, with 70-80% of healthcare decisions dependent on timely pathology-based tests, a demand that is expected to grow. Fourier ptychography…
Chest Pain Assessment Tool (CPAT), a fast and convenient chest pain diagnosis decision aid software
Unmet Need Heart disease is the leading cause of death in the US. More than 7 million people present annually to emergency departments with symptoms of chest pain. Nearly 2% are misdiagnosed as not having…
GOPTICAS: Systems and methods for measurements of Gross Primary Production (GPP)
Unmet Need Over geological timescales, nearly half of the world’s atmospheric oxygen (O2) has been generated in the ocean by marine organisms such as algae, plankton and seaweed. These organisms synthesize oxygen based off the…
Identification and application of novel lipoglycodepsipeptide antibiotics
Unmet Need Antibiotic resistance (ABR) is a global public health concern. In 2019, an estimated five million deaths were attributed to antibiotic resistant pathogens. A recent study estimates that ABR could cause nearly ten million…
Advanced remote monitoring and prediction of deep-seated landslide risk using SAR and physical modeling
Unmet Need Deep-seated landslides are some of the most catastrophic natural hazards, gradually moving almost imperceptibly over many years before suddenly collapsing in a dramatic fashion. Conventional prediction methods depend on physical access through boreholes,…
A semiconducting material that switches between glass and crystalline states at lower temperatures than conventional inorganic semiconductors
Unmet Need In recent times, different forms of inorganic glasses have emerged that are distinct from what human civilization has been using for more than 5,000 years. Due to the advent of such glasses, a…
Line-scan phase-resolved synthetic wavelength LiDAR using an off-axis holographic approach
Unmet Need High-resolution three-dimensional (3D) imaging techniques have seen widespread adoption as a means by which to develop a real-time map of the world around us, such as is needed by a variety of autonomous…
Methods to implement three-dimensional (3D) sensing depth cameras
Unmet Need Real-time high-resolution three-dimensional (3D) imaging is highly desirable in a wide range of fields including biomedical imaging, robotics, virtual/augmented reality, 3D printing, and autonomous vehicles. To accomplish 3D imaging, sensing depth cameras have…