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Automated segmentation of layered structures such as retinal layers using graph cuts
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges.…
XCAT phantom CT projector
The XCAT, MOBY, and ROBY phantoms include a great amount of anatomical detail that make them suitable for use in high-resolution CT imaging research. To simulate CT imaging process, we developed a CT projector that…
Detailed brain model for imaging research
The XCAT brain phantom program includes a highly detailed anatomy for the human brain. Over 100 structures and vessels are modeled based on MRI data. The program will generate voxelized versions of the brain at…
XCAT library of anatomical models for CT imaging research
In addition to the standard male and female adult anatomies of the XCAT, we also developed several other models based on CT imaging data. Each model includes the same amount of detail as the original…
Techniques for the segmentation of layered structures using graph theory and dynamic programming
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges.…
Chemical modulators of immune checkpoints and therapeutic use
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The…
Gene targeting to the ROSA26 locus
Plasmids for gene modification unitlizing zink finger sequences targeting ROSA locus. Publication: P Perez-Pinera, DG Ousterout, MT Brown, CA Gersbach. Gene Targeting to the ROSA26 Locus Directed by Engineered Zinc Finger Nucleases. Nucleic Acids Res…
Novel dystonia treatment drugs
Value Proposition Dystonia is a movement disorder characterized by sustained, often painful involuntary postures, causing motor disabilities and a marked decrease in quality of life. Dystonia is the third most common movement disorder behind Parkinson’s…
Replication competent bi- and tri-valent influenza viruses as vaccines
Value Proposition Influenza infection is a major public health concern, with an estimated 200,000 Americans hospitalized each year with flu or flu-related illness. The most effective method for flu prevention is vaccination, however, due to…
A humanized mouse model of Duchenne Muscular Dystrophy
This is a novel mouse model containing the full length human dystrophin gene harboring a mutation that models the cause of Duchenne muscular dystrophy. No mouse dystrophin is made, such that therapeutics focused on correction…
Real-time optical coherence tomography processing software
Value Proposition Optical coherence tomography (OCT) has revolutionized retinal diagnostics and is rapidly expanding into surgical settings. Currently, surgical OCT systems are limited to visualization of 2D images of live surgery. This resulted in difficulties…
Endoscopic optical assessment of tissue histology
Value Proposition Endoscopy is an extremely important and prevalent procedure for the diagnosis of a variety of disorders affecting the esophageal and gastrointestinal tracts such as colorectal cancer, adenoma, inflammatory bowel disease, and intestinal metaplasia.…