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SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
A predictive model for early detection of psychiatric risk in adolescents
Unmet Need According to the World Health Organization, nearly 15% of adolescents (10 to 19-year-olds) experience a mental health condition, many of which remain undiagnosed and untreated. Since the beginning of the COVID-19 pandemic, the…
Temporally Dependent Iterative Expansion (TEDIE), a novel algorithm that accurately identifies seizure-causing epileptic zones in the brain
Unmet Need Epilepsy is one of the most common neurological diseases in the world. As of 2023, approximately 50 million people live with epilepsy globally, and for these patients, premature death is up to 3…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
Unmet Need Current mitochondrial network analysis tools require significant manual intervention, making them labor-intensive, subjective, and prone to variability. These limitations hinder the reproducibility and accuracy needed for studying complex mitochondrial morphologies in disease diagnostics,…
Rapid, responsive, and active dissection insertion device for large-bore chest tubes
Unmet Need Tube Thoracostomy, a critical procedure for removing fluids and/or air from around the lungs to restore breathing, has a high complication rate of 30%, with complications increasing cost by up to 21x. This…
Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Alternating Hemiplegia of Childhood (AHC) is a rare neurologic disorder affecting children, causing episodes of temporary paralysis, dystonia, and severe behavioral issues, with prevalence estimates ranging from 1 in 1 million to 1…
3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Radiation Treatment Planning Software with Integrated Computer Aided Tumor Detection
Unmet Need Radiation is an effective component of cancer therapeutics and is utilized in approximately 50% of all cancer cases. For treatment to be effective, a treatment plan must be created that takes into consideration…
Systems and methods for predicting real-time behavioral risks using everyday images
Unmet Need Daily environments can significantly impact health outcomes, influencing factors such as stress, sleep, nutrition, and harmful behaviors. Fall risk is a major concern, particularly for older adults, with environmental factors like poor lighting…
Method to produce durable synthetic rubbers that exhibit strain-induced crystallization (SIC) at ambient temperature
Unmet Need Polybutadiene is a synthetic rubber with high elasticity, resistance to wear, and robust ability to return to its original shape following deformation. These desirable characteristics have led to widespread use within manufacturing, namely…
Next-Generation Protein Linkers: Enhancing Stability and Targeting in Bioengineered Therapeutics
Unmet Need In protein bioengineering, stable and effective fusion proteins are crucial for therapeutic and diagnostic applications. However, current protein linkers often fail to maintain the stability, bioactivity, and targeted functionality needed, leading to limitations…