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Gene therapy for ATP1A3-Related Neurologic Disorders
Unmet Need Alternating Hemiplegia of Childhood (AHC) is a rare neurologic disorder affecting children, causing episodes of temporary paralysis, dystonia, and severe behavioral issues, with prevalence estimates ranging from 1 in 1 million to 1…
Innovative bispecific T cell engager targeting phosphatidylserine for solid tumor immunotherapy
Unmet Need While cancer immunotherapy has revolutionized treatment of leukemias and lymphomas in recent years, its application to solid tumors has lagged. The reasons for reduced efficacy of CAR-T cells against solid tumors is an…
Temporally Dependent Iterative Expansion (TEDIE), a novel algorithm that accurately identifies seizure-causing epileptic zones in the brain
Unmet Need Epilepsy is one of the most common neurological conditions, affecting approximately 50 million people worldwide as of 2023. Patients with epilepsy face a risk of premature death up to three times higher than…
Personalized Behavioral Risk Prediction Technology
Unmet Need Daily environments significantly influence mental and physical health, impacting factors like stress, sleep quality, and behaviors tied to addiction and mental health conditions. For example, specific environments may trigger smoking, exacerbate insomnia, or…
Optimized hard-decision decoding for generalized product codes in high-speed communication systems
Unmet Need Communication channels often introduce errors due to noise, leading to the need for robust error control mechanisms. While techniques like forward error correction (FEC) add redundant bits to detect and correct transmission errors,…
Antigenome Platform: An autoantigen discovery pipeline
Unmet Need The human body contains approximately 60 trillion antibodies per microliter of blood in circulation, creating a vast and complex network of immune interactions. Identifying the targets of this plethora of antibodies is a…
Real-time monitoring and intervention of specific behaviors by simultaneous recordings of multiple brain regions
Unmet Need There is a need for more effective and precise methods to predict and regulate neurological behaviors, such as aggression, in mammals. Current treatments and behavioral interventions often fail to accurately prevent the onset…
Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration
Unmet Need Gap junctions are crucial for enabling the direct flow of ions and small molecules between cells, playing a significant role in synchronizing electrical activity in organs like the heart and brain. However, mutations…
Depth-Resolved Spectroscopic Imaging System for Early Cancer Detection and Diagnosis
Unmet Need Colorectal and esophageal cancers rank among the leading causes of cancer deaths in the United States. Early detection through screening is key to reducing mortality rates. Current screening methods, like colonoscopy for colorectal…
Automated cell membrane tension controller for studying mechanotransduction
Unmet Need Force-gated ion channels embedded in the cell membrane are central to mechanotransduction – the process by which mechanical forces are converted into electrochemical signals that regulate cellular behaviors such as motility, adhesion, and…
SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…