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Showing 6 matches for the following: Inventor: "Sullenger, Bruce" ×
Functionalized microfiber mesh for inflammation and thrombosis prevention
Unmet Need Trauma is a significant global health issue responsible for approximately 10% of deaths and over 15% of disabilities worldwide according to the World Health Organization. In addition to physical injuries, trauma-induced inflammation plays…
A universal antidote for aptamer therapeutics
Value Proposition With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to…
Ex vivo scavenging of pro-inflammatory nucleic acids by electrospun cationic nanofibers
Value proposition Chronic wounds are a challenge to treat and consume a great deal of healthcare resources around the globe. In the setting of chronic wounds, dead and dying cells are continuously releasing nucleic acids…
Inhibition of endosomal TLR-activation with nucleic acid binding polymers
Value Proposition Inflammatory and autoimmune diseases are the result of improper activation of the immune system, and can have chronic debilitating effects on quality of life. This inflammation is mediated by pattern recognition receptors (PRRs)…
Development of novel therapeutic splice-switching oligonucleotides against aggressive prostate cancer
Value Proposition One in twelve men will be diagnosed with prostate cancer in their lifetime. Castration resistant prostate cancer, which resists traditional hormone therapies and continues to grow and often metastasize with poor survival outcomes,…
Aptamers to VMF
Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific…