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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
A highly sensitive next-generation sequencing technique for detecting cancerous mutations
Unmet Need Next-generation sequencing (NGS) methods have been widely adopted for both biological discovery and diagnostics in cancer patient care. In particular, the identification of new mutations or groups thereof arising within oncogenic pathways across…
Breast cancer risk prediction technology using genomic classifier
Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
A novel acoustic biomarker for quality of life in LVAD recipients
Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. According to St. Judes, in the U.S. in 2016, over 7% of LVAD users reported poor…
A platform for high-throughput quantification of gap junction hemichannel docking
Unmet Need Gap junctions are transmembrane channels that facilitate for cell-cell communication. They play a crucial role in normal cellular physiology and their dysfunction or misregulation is associated with many human diseases. Gap junctions are…
Enclosure device to track fine-scale movements of animals in 3D with a single camera
Unmet Need A major component of medical research and preclinical drug development is to identify subtle behavioral phenotypes in animal models. This has led to progress in studies of depression, anxiety, cognitive disorders, and neurological…
Detection and measurement of RNA modifications through targeted RNA editing
Value Proposition N6-methyladenosine, m6A, is the most frequent post-transcriptional modification in RNA that has been implicated in nearly every aspect of the RNA life cycle. Furthermore, proteins involved in the formation, removal, and recognition of…
Method of growing and analyzing single cells within microfluidic droplets
Unmet Need The importance and influence of the microbiome on human health is becoming increasingly recognized, with the human microbiome linked to processes varying widely across the body. Accumulating data suggests that the microbiome plays…
A system for screening compounds that alter smell perception
Unmet Need Olfactory sensation profoundly influences a person’s quality of life. In addition to the aesthetic aspects of life associated with olfactory sensation, approximately 2 million Americans experience some type of olfactory dysfunction. Studies show…
Screening method to identify lead compounds to treat hereditary neurological disorders and other diseases associated with MutSβ activity
Unmet Need The human genome is constantly under the threat of DNA damage and replication errors that can result in mutations. A heterodimer of DNA mismatch repair proteins named MutSβ has been linked to a…
A method for identifying sour-taste receptor ligands as well as compounds that modulate their activity
Unmet Need The taste system is essential for feeding and survival as it helps humans evaluate the nutritional content in food. Every year, taste and smell dysfunctions affect more than 200,000 people, including those undergoing…