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Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
A fluorescent probe for monitoring beta-secretase activity in cells
Unmet Need Alzheimer’s Disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) plaques, which lead to neurotoxicity, synaptic damage, and neuronal cell death. Current therapeutic approaches face significant challenges due to the complex nature…
Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis
Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…
The Chronic Overlapping Pain Condition Screener
Unmet Need Ten Chronic Overlapping Pain Conditions (COPCs) are currently recognized by the National Institutes of Health Pain Consortium (eg, irritable bowel syndrome, chronic migraine headache, and chronic low back pain). These conditions affect millions…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
A highly sensitive next-generation sequencing technique for detecting cancerous mutations
Unmet Need Next-generation sequencing (NGS) methods have been widely adopted for both biological discovery and diagnostics in cancer patient care. In particular, the identification of new mutations or groups thereof arising within oncogenic pathways across…
Breast cancer risk prediction technology using genomic classifier
Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…
A novel acoustic biomarker for quality of life in LVAD recipients
Unmet Need Left ventricular devices (LVADs) are surgically implanted pumps that improve survival in patients with advanced heart failure. According to St. Judes, in the U.S. in 2016, over 7% of LVAD users reported poor…
A platform for high-throughput quantification of gap junction hemichannel docking
Unmet Need Gap junctions are transmembrane channels that facilitate for cell-cell communication. They play a crucial role in normal cellular physiology and their dysfunction or misregulation is associated with many human diseases. Gap junctions are…
Detection and measurement of RNA modifications through targeted RNA editing
Value Proposition N6-methyladenosine, m6A, is the most frequent post-transcriptional modification in RNA that has been implicated in nearly every aspect of the RNA life cycle. Furthermore, proteins involved in the formation, removal, and recognition of…
Method of growing and analyzing single cells within microfluidic droplets
Unmet Need The importance and influence of the microbiome on human health is becoming increasingly recognized, with the human microbiome linked to processes varying widely across the body. Accumulating data suggests that the microbiome plays…
A system for screening compounds that alter smell perception
Unmet Need Olfactory sensation profoundly influences a person’s quality of life. In addition to the aesthetic aspects of life associated with olfactory sensation, approximately 2 million Americans experience some type of olfactory dysfunction. Studies show…