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iPSC line to identify novel therapies for ARVC
Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
Stable Cell lines expressing nAChR subunits
About Nicotinic Acetylcholine Receptors (nAChR) Nicotinic acetylcholine receptors (nAChR) are receptor proteins that respond to the neurotransmitter acetylcholine, and respond to drugs including nicotine. When nAChR are activated, the cells release dopamine and other neurotransmitters,…