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3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Feature-free photogrammetric 3D imaging with cameras under unconstrained motion
Unmet Need With the increasing development of camera-based sensors for applications such as virtual and augmented reality, there is more demand for technologies that can image 3D structures and create interpretable digital representations – a…
Dark-Blood Delayed-Enhancement MRI: Improved Tissue Contrast and Blood-Pool Signal Suppression
Unmet Need Delayed-enhancement MRI (DE-MRI) is the standard for imaging myocardial infarction (MI), providing high-resolution maps of infarcted and viable myocardium. However, DE-MRI often suffers from poor differentiation between infarcted myocardium and the bright left…
MRI method for detecting partial fatty tissue infiltration within the body
Unmet Need Through magnetic resonance imaging (MRI), it is possible to image and differentiate tissues and biological elements throughout the body. However, due to some tissues of the body having similar chemical compositions and subsequent…
Vectorial Fourier ptychography for high-resolution widefield polarization imaging in pathology and research
Unmet Need In the United States, over 10,000 diagnostic imaging centers rely on microscopy for diagnostics, with 70-80% of healthcare decisions dependent on timely pathology-based tests, a demand that is expected to grow. Fourier ptychography…
Advanced remote monitoring and prediction of deep-seated landslide risk using SAR and physical modeling
Unmet Need Deep-seated landslides are some of the most catastrophic natural hazards, gradually moving almost imperceptibly over many years before suddenly collapsing in a dramatic fashion. Conventional prediction methods depend on physical access through boreholes,…
Line-scan phase-resolved synthetic wavelength LiDAR using an off-axis holographic approach
Unmet Need High-resolution three-dimensional (3D) imaging techniques have seen widespread adoption as a means by which to develop a real-time map of the world around us, such as is needed by a variety of autonomous…
Methods to implement three-dimensional (3D) sensing depth cameras
Unmet Need Real-time high-resolution three-dimensional (3D) imaging is highly desirable in a wide range of fields including biomedical imaging, robotics, virtual/augmented reality, 3D printing, and autonomous vehicles. To accomplish 3D imaging, sensing depth cameras have…
Non-invasive peripheral retinal scanner using OCT
Unmet Need Images and light that sporadically appear in an individual’s visual field are known as “Flashes and floaters.” These optical aberrations bring approximately 150,000 patients in for eye exams each year in the United…
A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging
Unmet Need Color-flow ultrasound imaging is a technique that allows for visualization of blood flow within tissues and is frequently used to diagnose cardiovascular abnormalities, guide needle biopsies, examine tumor vascularity, and measure blood flow…
A microscopy method for acquiring polarization-sensitive phase information in 3D
Unmet Need The majority of biological research and clinical diagnostics has involved the use of optical imaging systems for transparent specimens that rely on scalar properties like phase contrast. These systems have proved useful for…
A computer vision approach for molecular subtyping of breast cancer using MRI
Unmet Need Breast cancer is the second leading cause of cancer-related deaths in American women and the fourth most common cause of all cancer-related deaths in the U.S. While early screening for cancer using magnetic…