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Type I CRISPR-Cas expands the human genome engineering toolkit

Type I CRISPR-Cas expands the human genome engineering toolkit

Unmet Need Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Associated Systems (Cas) provide immune protection to bacteria and archaea. CRISPR-Cas systems can be mono-subunit (Class 2) or multi-subunit (Class 1). Class 2 CRISPR-Cas systems, especially Type…

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Perfusate for optimized gene delivery to donor organs undergoing ex vivo machine perfusion

Perfusate for optimized gene delivery to donor organs undergoing ex vivo machine perfusion

Unmet Need Effective gene delivery is notoriously difficult to achieve to an entire target organ. Gene therapies have traditionally been administered intravascularly, requiring high vector doses to attain therapeutic levels of expression. Because of this…

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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…

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Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma

Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma

Unmet Need Chimeric Antigen Receptor (CAR) T-cell therapy, a form of immunotherapy, has proven highly effective against blood cancers such as leukemias and lymphomas. This therapy uses T-cells that are genetically engineering ex vivo to…

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Collection of novel CRISPR guide RNAs and their creation method

Collection of novel CRISPR guide RNAs and their creation method

Unmet Need The advent of CRISPR-Cas9 technology has enabled targeted rapid modification of genes and sparked a biotechnology revolution. The CRISPR-Cas9 complex is composed of two parts: a guide RNA specific to the DNA sequence…

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Gene therapy for long-term treatment of Pompe disease

Gene therapy for long-term treatment of Pompe disease

Unmet Need Pompe disease is a rare heritable disorder impacting heart and skeletal muscle function with an estimated incidence rate of 1 in 40,000 births in the US. Of these affected births, a third take…

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Gene therapy for long-term treatment of GSDIa

Gene therapy for long-term treatment of GSDIa

Unmet Need Glycogen storage disease type Ia (GSDIa), or von Gierke disease, is a rare heritable metabolic disorder that impacts the liver and kidneys due to an inability to break down glycogen. An estimated 1…

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High-stringency method for the isolation and proteomic identification of RNA binding proteins

High-stringency method for the isolation and proteomic identification of RNA binding proteins

Unmet Need RNA binding proteins (RBPs) play a critical role in maintaining stable gene expression, and they are involved in several related functions throughout eukaryotic cells, including splicing and translation. RBPs interact with RNA in…

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Methods and compositions for treating protein aggregation diseases

Methods and compositions for treating protein aggregation diseases

Unmet Need Neurodegenerative disease affects more than 50 million people per year. Certain neurodegenerative diseases, like Alzheimer’s disease, result from the accumulation of amyloid-forming proteins in the brain, which results in cognitive impairment and has…

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Novel epigenome editors for multiplexed gene regulation

Novel epigenome editors for multiplexed gene regulation

Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…

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Blood pressure control by gene editing

Blood pressure control by gene editing

Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. Currently available drugs used to control blood pressure can be effective but are limited by…

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Method for rapid regeneration of modifiable stable cell lines

Method for rapid regeneration of modifiable stable cell lines

Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…

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