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SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
Precision Gene Therapy for Parkinson’s Disease: Targeted SNCA Down-regulation in Dopaminergic Neurons
Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting approximately 10 million people globally and 1 million in the U.S. PD is characterized by involuntary movements such as tremors, stiffness, and…
Targeted delivery of gene therapy via exosomes for cardiomyocyte reprogramming
Unmet Need Every year, close to 1 million Americans experience a heart attack. A heart attack results in the loss of specialized cells called cardiomyocytes, which are crucial for the heart’s contraction and rhythmic beating.…
Method to trap and transport small particles with acoustic forces
Value Proposition Acoustic tweezers use ultrasound to create radiation force potential wells that enable precise and contact-free manipulation of physical and biological objects across a broad object size range. It is a fast-developing platform that…
Novel Self-Assembling Nanoparticles for Extended Duration Local Anesthetics
Unmet Need An estimated 40 million surgeries are performed every year in the United States. Out of this population, an estimated 80% had post-operative pain with 75% reporting it as moderate to extreme. Local anesthetics…
Type I CRISPR-Cascade: precise gene modulation platform for human cell applications
Unmet Need The gene editing sector has experienced a transformative surge in technological advancements with the emergence of CRISPR-Cas systems. These systems offer unprecedented capability to modify and modulate genetic sequences, proving instrumental from fundamental…
Type I CRISPR-Cas expands the human genome engineering toolkit
Unmet Need Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Associated Systems (Cas) provide immune protection to bacteria and archaea. CRISPR-Cas systems can be mono-subunit (Class 2) or multi-subunit (Class 1). Class 2 CRISPR-Cas systems, especially Type…
Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 21% predicted to occur until 2027. Medical and dental products account for the…
A synergistic chemotherapy and radiotherapy drug delivery technology for treating prostate cancer tumors
Unmet Need Pancreatic cancer is one of the deadliest manifestations of cancer in clinical oncology. Despite accounting for only 3.2% of all cancer cases, it is the third leading cause of cancer-related mortality. National Comprehensive…
Anti-cancer therapeutic for the induction of apoptosis in solid tumors via TRAIL receptors
Unmet Need Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL, CD253) acts as an activator of apoptosis in many tumor cells, while remaining innocuous to normal cells. Both membrane-bound and soluble forms of TRAIL can trigger apoptosis…
Flexible needle for targeted delivery of chronic pain treatment
Unmet Need For patients suffering from chronic pain associated with degenerative changes, inflammation, neuropathy or cancer, the ability to carry out daily life and work activities is a challenge. Current treatment methods are limited and…
Enzymatic synthesis of aptamer-targeted polynucleotide drug delivery platforms for cancer therapy
Unmet Need In the United States alone, over 1.8 million new patients were diagnosed with cancer in 2021, and over 600,000 patients died from the disease. Cytostatic nucleotides, such as gemcitabine and 5-fluorouracil, have been…