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Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients

Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…

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Duke Anesthesia Resistance Scale (DARS), a postoperative delirium risk calculator

Duke Anesthesia Resistance Scale (DARS), a postoperative delirium risk calculator

Unmet Need More than 70 million surgeries are performed on older adults annually worldwide. The combined burden of anesthesia, surgery, and postoperative hospitalization increase risk of developing postoperative delirium in aging patients. Delirium is associated with…

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Non-invasive method to predict rates of post-operative cognitive problems

Non-invasive method to predict rates of post-operative cognitive problems

Unmet Need Older adults are at a higher risk of cognitive dysfunction after surgery, with postoperative delirium (POD) being the most common disorder. POD is characterized by inattentiveness and is seen in 70-80% of intensive…

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Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism

Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…

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A novel non-addictive method for treating neuropathic pain associated with cancer

A novel non-addictive method for treating neuropathic pain associated with cancer

Unmet Need In the US alone, close to 1.9 million new cases of cancer are diagnosed each year and 44.5% of these patients will experience chronic pain. This type of chronic pain, called neuropathic pain,…

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Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment

Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment

Unmet Need Breast cancer is the most common non-skin cancer in women in the United States, accounting for 1 in 3 of all new female cancers each year. Breast conserving surgery is a common treatment…

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Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Clinically-Linked ECG and Arrhythmia Repository (CLEAR)

Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…

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Bacterial voltage gated ion channels for cardiac reprogramming

Bacterial voltage gated ion channels for cardiac reprogramming

Unmet Need Untreated cardiovascular disease (CVD) can lead to irreversible heart damage. This occurs when ischemia — inadequate blood flow — leads to the death of heart muscle fibers that conduct electrical impulses. Consequently, scar…

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A biodegradable fixation device for breast implants

A biodegradable fixation device for breast implants

Unmet Need Breast augmentation and reconstruction is the 5th leading cosmetic surgery procedure of the 1.5 million cosmetic procedures done in the United States in 2020. About 12% of these procedures result in the implants…

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Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions

Zwitterionic-coated surgical mesh to minimize intra-abdominal adhesions

Unmet Need Four million abdominal surgeries are performed annually in the United States. Abdominal adhesions, or fibrous bands that bind tissue together, represent a significant postoperative complication occurring in >50% of patients undergoing abdominal surgery.…

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Improved beta oscillation burst detection for assessment of Parkinson’s disease

Improved beta oscillation burst detection for assessment of Parkinson’s disease

Unmet Need Parkinson’s disease is a debilitating ailment, though therapies such as deep brain stimulation via electrodes can improve symptoms. Such therapies rely on feedback from biomarkers to adjust the stimulation parameters. Such biomarkers may…

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Optically transparent model kidney for surgical simulation

Optically transparent model kidney for surgical simulation

Unmet Need Surgical simulation is an important step in medical training. It is particularly critical for training in the urological field, which had 144 residency programs in 2023. Lithotripsy, a surgical procedure to treat kidney…

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