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A method for selectively blocking nerve fibers during neurostimulation treatment using kilohertz frequency electrical signals
Unmet Need In the past three decades implanted neurostimulation devices have become widely adopted driven largely by their ability to treat a range of clinical conditions with a “drug-free” solution. The $6.6 billion dollar market…
A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy
Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…
HIV treatment and prevention using broadly neutralizing antibodies
Unmet Need For over 40 years, the human immunodeficiency virus (HIV) pandemic has affected the quality of life and decreased the life expectancy for millions of people with approximately 1.5 million new cases each year.…
Implant for identifying sites of seizure onset in the brain
Unmet Need In the United States, epilepsy affects 2.2 million people with 150,000 new cases each year. Between 14.6% and 36.3% of people who suffer from epilepsy have forms of epilepsy that are not controllable…
Gene therapy for long-term treatment of GSDIa
Unmet Need Glycogen storage disease type Ia (GSDIa), or von Gierke disease, is a rare heritable metabolic disorder that impacts the liver and kidneys due to an inability to break down glycogen. An estimated 1…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
An effective method for treating functional gastrointestinal and motility disorders using patterned electrical stimulation in the colon
Unmet Need Functional gastrointestinal and motility disorders (FGIMD) impact 1 in 5 persons in the U.S. It is a group of disorders classified by GI symptoms which include irritable bowel syndrome, fecal incontinence, constipation, and…
A new therapeutic target for preventing hair loss in chemotherapy-treated cancer patients
Unmet Need Losing one’s hair is a profoundly unnerving phenomenon that affects daily life, social relationships, and even one’s own confidence. While about 2% of the world’s population suffers from general hair loss, it is…
A method to enable the use of a novel biomarker for deep brain stimulation treatments
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…
Methods and compositions for treating protein aggregation diseases
Unmet Need Neurodegenerative disease affects more than 50 million people per year. Certain neurodegenerative diseases, like Alzheimer’s disease, result from the accumulation of amyloid-forming proteins in the brain, which results in cognitive impairment and has…
A method to improve deep brain stimulation treatments by using cortical evoked potentials as a biomarker
Unmet Need Neuromodulation therapies are used to treat a wide variety of clinical conditions. For example, an estimated 150,000 deep brain stimulation (DBS) implants are performed globally to help treat movement disorders like Parkinson’s Disease.…
