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A computer vision approach for molecular subtyping of breast cancer using MRI
Unmet Need Breast cancer is the second leading cause of cancer-related deaths in American women and the fourth most common cause of all cancer-related deaths in the U.S. While early screening for cancer using magnetic…
A highly sensitive next-generation sequencing technique for detecting cancerous mutations
Unmet Need Next-generation sequencing (NGS) methods have been widely adopted for both biological discovery and diagnostics in cancer patient care. In particular, the identification of new mutations or groups thereof arising within oncogenic pathways across…
RXR modulators to improve the efficacy of immunomodulatory agents in multiple myeloma treatment
Unmet Need Multiple myeloma (MM) is the second most common hematological malignancy in the United States. Although current anti-myeloma therapeutics help patients live with the disease for more than 10 years, MM remains an incurable…
Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
Pancreatic cancer treatment that inhibits the Piezo1/TRPV4 axis
Unmet Need Pancreatic cancer has one of the highest mortality rates of all cancer types in the US. The American Cancer Society predicts that about 64,000 people will be diagnosed with pancreatic cancer and 55,000…
T-cell releasing antibody for breast cancer tumor metastasis prevention
Unmet Need Metastatic breast cancer is a deadly form of breast cancer with only 1/3 of patients diagnosed with it living to 5 years post-diagnosis. Metastasis can occur either at disease onset (6% of patients)…
Method to enable cancer immune checkpoint therapy
Unmet Need Cancer remains to be a heavy burden on Americans as many current gold-standard treatments can be ineffective. In 2022, an estimated 623,000 Americans were living with metastatic cancer and is predicted to increase…
A novel T-cell-based immunotherapy for brain cancer
Unmet Need Cancer immunotherapy represents a new paradigm in cancer treatment with the goal of harnessing the immune system to selectively attack a patient’s tumor. T-cell-based immunotherapies encompass chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes,…
Using oxidative cell death to target RB1-deficient prostate cancer
Unmet Need In the first quarter of 2023, there were approximately 288,300 Americans diagnosed with prostate cancer, accounting for about 15% of all new cancer diagnoses. The five-year survival rate of patients with prostate cancer…
A novel immune competence blood test to predict responsiveness of tumors to cancer immunotherapy
Unmet Need Cancer immunotherapy provides great advantages over traditional cytotoxic chemotherapy and radiation with more durable clinical outcomes and an improved quality of life. The number of US patients eligible for immunotherapy was estimated to…
A new therapeutic target for preventing hair loss in chemotherapy-treated cancer patients
Unmet Need Losing one’s hair is a profoundly unnerving phenomenon that affects daily life, social relationships, and even one’s own confidence. While about 2% of the world’s population suffers from general hair loss, it is…
Breast cancer risk prediction technology using genomic classifier
Unmet Need The earliest form of breast cancer, ductal carcinoma in situ (DCIS), is diagnosed in almost 50,000 people in the U.S. each year. DCIS is considered noninvasive, as abnormal cells have not spread out…