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Acoustofluidic technologies for precision control in microfluidic systems
Unmet Need Achieving precise manipulation of particles, cells, and droplets in microscale liquid systems is a major challenge in life sciences, material sciences, and chemistry. Traditional microfluidic systems, which use hydrophobic channels and pressure differentials…
Novel RNA-based anti-cancer therapeutic for sustained immunotherapy by combined pattern recognition receptor (PRR) activation and anti-microRNA therapy (AMT)
Unmet Need Cancer is incredibly prevalent and current therapies are insufficient. Globally, lifetime prevalence is 1 in 5, and mortality is 1 in 9 in men and 1 in 12 in women. Solid tumors account…
Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment
Unmet Need Breast cancer is the most common non-skin cancer in women in the United States, accounting for 1 in 3 of all new female cancers each year. Breast conserving surgery is a common treatment…
A novel non-addictive method for treating neuropathic pain associated with cancer
Unmet Need In the US alone, close to 1.9 million new cases of cancer are diagnosed each year and 44.5% of these patients will experience chronic pain. This type of chronic pain, called neuropathic pain,…
New small molecules targeting castration-resistant prostate cancer
Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…
Revolutionary inhibitor target for enhanced immune response against breast cancer relapse
Unmet Need In the US, it is estimated that 1 in 8 women will develop breast cancer, of which 78% are estrogen receptor-positive (ER+) cases. These ER+ breast cancers are known for their risk of…
Therapy for neurotensin positive cancers
Unmet Need Under normal conditions, neurotensin signaling is largely constrained to the nervous system. However, abnormal expression is seen in cancers that are aggressive or have a poor prognosis such as pancreatic, which has a12.5%…
Adoptive T-cell immunotherapy to treat cancer caused by Epstein-Barr virus
Unmet Need Epstein-Barr virus (EBV) is an infectious disease that has been shown to cause a number of cancers originating from EBV-afflicted cells. Across the globe, EBV is associated with approximately 200,000 cases of malignancies…
Anti-LYPD3 CAR T-cell therapy for the treatment of squamous cell carcinoma
Unmet Need Chimeric Antigen Receptor (CAR) T-cell therapy, a form of immunotherapy, has proven highly effective against blood cancers such as leukemias and lymphomas. This therapy uses T-cells that are genetically engineering ex vivo to…
A computer vision approach for molecular subtyping of breast cancer using MRI
Unmet Need Breast cancer is the second leading cause of cancer-related deaths in American women and the fourth most common cause of all cancer-related deaths in the U.S. While early screening for cancer using magnetic…