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Surface acoustic wave based separation techniques
Value Proposition Complex biofluids such as blood, urine etc. contain a plethora of particles of interest that are of diagnostic and research interest. Examples of such particles may include exosomes, or Circulating Tumor Cells (CTC).…
Gene signature for prediction of acute rejection in kidney transplant
Unmet Need Kidney transplant is the best current treatment for kidney failure. The kidney is the most common organ to be transplanted, and in 2019 there were 23,405 kidney transplants in the United States. Unfortunately,…
Method to overcome treatment resistant cancer by rescuing STING signaling
Unmet Need Among types of brain cancer, glioblastoma (GBM) is the most common and the most devastating. Over 8000 patients are diagnosed annually in the United States, accounting for half of all primary malignant brain…
Metabolite biomarkers of human heart failure
Value Proposition Heart failure is a very common condition affecting approximately 5.1 million people in the United States. Due to its association with age, the incidence of heart failure, as well as the cost of…
Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients
Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…
Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism
Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…
New small molecules targeting castration-resistant prostate cancer
Unmet Need Prostate cancer (PC) is the second most common male cancer globally and represents 15% of all cancers diagnosed in males. An estimated 34,700 deaths were predicted to occur from PC in the U.S.…
Gene expression assay to determine radiation exposure
Unmet Need Ionizing radiation poses a significant risk as an environmental hazard and is linked to the development of multiple cancers in adults and children. Healthcare professionals, nuclear power plant employees, and research scientists are…
Extracellular vesicle biomarkers for detecting severity and progression of knee osteoarthritis
Unmet Need Osteoarthritis (OA) is a chronic degenerative joint disease that can impact the hands, knees, neck, lower back, and hips, leading to pain and restrictive mobility from the breakdown of connective tissue in these…
Olfactory neuroblastoma mouse model
Unmet Need Olfactory neuroblasoma (ONB) is an agressive tumor that is thought to arise in basal stem cells in the adult olfactory epithelium. This rare cancer affects 1 in 2.5 million people each year with…
Structural variants of TERT in brain tumors
Unmet Need Glioblastoma is the most common type of malignant brain tumor, and accounts for 47.7% of all brain cancer cases. Despite aggressive treatment, the median overall survival for glioblastoma is 15 to 18 months.…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…