- Agriculture
- Antibiotic/anti-viral
- Biologics
- Biomarkers
-
By Clinical Application
- Anesthesiology
- Blood & Lymphatic Disease
- CNS & Neurosciences
- Dermatology
- Diabetes, Metabolism, Endocrinology & Obesity
- Ear, Nose, & Throat
- Emergency Services
- Gastroenterology & Digestive Disease
- General & Plastic Surgery
- Health Education, Medical Training and Operations
- Heart and Vascular
- Immunology, Autoimmune & Inflammation
- Infectious Diseases
- Mental Health
- Multiple clinical applications
- Musculoskeletal Disorders, Orthopedics/Bone
- Nephrology/Renal
- Oncology
- Ophthalmology
- Orphan Diseases
- Pediatrics
- Physical Medicine & Rehabilitation
- Radiology
- Regenerative Medicine / Tissue Engineering
- Reproductive Health: Obstetrics & Gynecology
- Respiratory & Pulmonary
- Surgery
- Transplantation
- Urology
- Wound Healing
- COVID-19
- Creative Works
- Diagnostics
- Drug Delivery
- Drug screening and discovery
- Energy, Cleantech & Environmental
- Engineering & Physical Sciences
- Gene therapy
- Imaging
- Materials
- Medical Devices
- Nutraceuticals
- Other
- Research & Design Tools
- RNAi/siRNA
- Sensors & Controls
- Small molecules
- Software & Information Technology
- Stem Cells
- Vaccines
Showing 8 matches for the following: Inventor: "McDonnell, Donald" ×
CaMKK2 as a target for cancer immunotherapy
Tumor cells have the remarkable ability to block the immune system, and in such a way escape the immune response. This is a major problem that causes cancer development and metastasis. The ability of tumor…
Novel therapeutic targets in the androgen receptor signaling pathway for prostate cancer
Unmet Need Prostate cancer is the most common malignancy in men. The most recent CDC data demonstrates that prostate cancer makes up 12.2% all new cancer cases in the U.S. at 207,430. Prostate cancers express…
Estrogen Receptor Action Indicator (ERIN) Mouse
To address globally the issue of tissue specificity of ER ligands, Duke scientists have developed a transgenic mouse that functions as a reporter of ER activity, termed ERIN (estrogen receptor action indicator). ERIN provides a…
Long term estrogen deprived tumor models 71, 73 and 75
Long term estrogen deprived tumor models 71, 73, and 75 are estrogen receptor positive xenograft tumor models that grow independent of estrogen exposure, thereby providing an in vivo tumor model of aromatase resistance in the…
A reporter gene C3-T1ba
Reporter Gene used to measure both estrogen and tamoxifen activated estrogen receptor transcriptional activity reconstituted in mammalian cells. Derived from the complement 3 (C3) promotor.
Cell line model of castration resistant prostate cancer
Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…
Cell line model of enzalutamide resistant prostate cancer
Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…