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GPR37 and GPR37L1 Agonists for Non-Addictive Pain Resolution in Inflammatory and Neuropathic Pain
Unmet Need Chronic pain remains a widespread clinical issue, with existing treatments primarily focused on symptom suppression rather than addressing the biological mechanisms driving pain persistence. Opioids and NSAIDs provide temporary relief but fail to…
Schenk Composer: A framework for algorithmic music generation
Unmet Need Music composition remains largely inaccessible to individuals without formal training in music theory, despite growing interest in AI-assisted creative tools. Existing AI-generated music solutions frequently produce results that are uninterpretable and unpredictable, offering…
PD-L1-Based Therapy for Non-Opioid Treatment of Chronic Pain
Unmet Need Chronic pain, including inflammatory, neuropathic, and cancer-related pain, remains difficult to manage without opioids, which pose risks of addiction and adverse side effects. Existing non-opioid treatments often fail to provide sufficient relief or…
TGF-β1-Secreting Bone Marrow Stromal Cell Therapy for Long-Lasting Neuropathic Pain Relief
Unmet Need Neuropathic pain remains a significant clinical challenge, with current treatments providing only temporary relief and failing to address the underlying neuroinflammatory mechanisms. Chronic nerve injury leads to persistent pain hypersensitivity, which is difficult…
Auto-aligning slit lamp for eye exams
Unmet Need At least 2.2 billion people in the world have vision impairment. In 2019, there were 60 million incident cases and 438.4 thousand years lived with disability of eye injury. Almost half of these…
Auto-aligning handheld optical coherence tomography probe
Unmet Need Optical coherence tomography (OCT) is an optical imaging modality that uses low-coherence light to non-invasively obtain high resolution ocular images of structures including the retina and optic nerve. OCT has advantages over other…
Microbial Growth Foundational Model
Unmet Need Microbial growth dynamics provide crucial insights into microbial populations, with applications in drug discovery, personalized medicine, and synthetic biology. Advances in the field have resulted in an ever-growing list of known microbe species…
Combat-Ready Pelvic Hemorrhage Stabilization: Lightweight Tourniquet-Extending Canteen Cover (TECC) for Junctional Wounds
Unmet Need Uncontrolled junctional hemorrhage, particularly in the pelvic region, is responsible for one in four potentially survivable military deaths. These injuries are frequently sustained from penetrating wounds in combat, and standard tourniquets are ineffective…
A predictive model for early detection of psychiatric risk in adolescents
Unmet Need According to the World Health Organization, nearly 15% of adolescents (10 to 19-year-olds) experience a mental health condition, many of which remain undiagnosed and untreated. Since the beginning of the COVID-19 pandemic, the…
Bioresorbable lactone-based elastomers that can be used in continuous digital light processing 3D printing applications
Unmet Need The global market for 3D printing, or additive manufacturing, is growing rapidly with a compound annual growth rate of approximately 21% predicted to occur until 2027. Medical and dental products account for the…
Nano-Scintillator Fiber Optic Dosimeter for Real-Time Radiation Detection
Unmet Need There is a need for accurate, real-time radiation detection across various industries, including healthcare, security, and manufacturing. Current scintillator-based detectors often suffer from limitations such as large spatial requirements, reliance on cryogenic cooling,…
Surface acoustic wave based separation techniques
Value Proposition Complex biofluids such as blood, urine etc. contain a plethora of particles of interest that are of diagnostic and research interest. Examples of such particles may include exosomes, or Circulating Tumor Cells (CTC).…