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Transcranial magnetic stimulation treatment for focal hand dystonia
Unmet Need Focal hand dystonia (FHD) is an involuntary movement disorder that occurs in an estimated 15 out of 1 million people. It causes sustained or intermittent muscle contractions that make it painful for people…
Learning to Detect Rowhammer Attacks on DRAMs
Description Rowhammer is a security vulnerability that arises due to the undesirable electrical interaction between physically adjacent rows in DRAMs. Bit flips caused by Rowhammer can be exploited to craft many types of attacks in…
A User-Customizable Modular Microplate Holder
Unmet Need Globally, laboratory accessories had an estimated market value of $504.7 million in 2020. Microplates and accessories represent 16% of this global market, which totals to $80.7 million. Manufacturers sell a variety of microplates…
Novel biomarkers to detect Venous Thrombosis without radiation exposure in elderly patients
Unmet Need Venous thrombosis/thromboembolism (VT/E), the formation of a blood clot in vein, can be a life-threatening condition with 600,000 incidences in the US per year and affecting an estimated 10 million people globally. VT/E…
Duke Anesthesia Resistance Scale (DARS), a postoperative delirium risk calculator
Unmet Need More than 70 million surgeries are performed on older adults annually worldwide. The combined burden of anesthesia, surgery, and postoperative hospitalization increase risk of developing postoperative delirium in aging patients. Delirium is associated with…
Transformative Peer coaching & training for young adults with chronic illness
Unmet Need An excellent alternative for the growing burden of chronic illness is patient-centered self-management. This method empowers patients to manage their condition actively, improving treatment outcomes and reducing the burden on healthcare providers. Self-management…
Complete in vivo Protein Lipidation through Dynamic Metabolic Control of Acyl-CoA Biosynthesis
Unmet Need Protein therapeutics and biologics are becoming more common in healthcare. However, these molecules often struggle to cross epithelial barriers or cause immune reactions, necessitating either injection or direct site administration to be effective.…
Non-invasive method to predict rates of post-operative cognitive problems
Unmet Need Older adults are at a higher risk of cognitive dysfunction after surgery, with postoperative delirium (POD) being the most common disorder. POD is characterized by inattentiveness and is seen in 70-80% of intensive…
Database of PET Images positive for Cardiac Sarcoidosis
Description The Clinical Database consists of PET scan images for 4 patients (FDG+Ammonia PET) only who have been identified as positive for cardiac sarcoidosis collected, annotated and compiled by DUKE and subject to Duke University…
Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism
Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…
Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network
Unmet Need Extreme ultraviolet (EUV) lithography is a patterning method that is at the forefront of semiconductor fabrication technology. EUV lithography uses wavelengths of light that are as small as 13 nm to produce incredibly…
Automated Method for De-Identifying Digital Imaging and Communications in Medicine Meta-Data and Burned-in Pixel Text
Unmet Need Clinical data that is organized and contains detailed patient information is critical for effectively treating high volumes of patients. One such form of clinical data includes medical images like magnetic resonance imaging (MRI),…