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Antigenome Platform: An autoantigen discovery pipeline
Unmet Need The human body contains approximately 60 trillion antibodies per microliter of blood in circulation, creating a vast and complex network of immune interactions. Identifying the targets of this plethora of antibodies is a…
Real-time monitoring and intervention of specific behaviors by simultaneous recordings of multiple brain regions
Unmet Need There is a need for more effective and precise methods to predict and regulate neurological behaviors, such as aggression, in mammals. Current treatments and behavioral interventions often fail to accurately prevent the onset…
Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration
Unmet Need Gap junctions are crucial for enabling the direct flow of ions and small molecules between cells, playing a significant role in synchronizing electrical activity in organs like the heart and brain. However, mutations…
Depth-Resolved Spectroscopic Imaging System for Early Cancer Detection and Diagnosis
Unmet Need Colorectal and esophageal cancers rank among the leading causes of cancer deaths in the United States. Early detection through screening is key to reducing mortality rates. Current screening methods, like colonoscopy for colorectal…
Automated cell membrane tension controller for studying mechanotransduction
Unmet Need Force-gated ion channels embedded in the cell membrane are central to mechanotransduction – the process by which mechanical forces are converted into electrochemical signals that regulate cellular behaviors such as motility, adhesion, and…
SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…
Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
Unmet Need Current mitochondrial network analysis tools require significant manual intervention, making them labor-intensive, subjective, and prone to variability. These limitations hinder the reproducibility and accuracy needed for studying complex mitochondrial morphologies in disease diagnostics,…
Rapid, responsive, and active dissection insertion device for large-bore chest tubes
Unmet Need Tube Thoracostomy, a critical procedure for removing fluids and/or air from around the lungs to restore breathing, has a high complication rate of 30%, with complications increasing cost by up to 21x. This…
3D cavitation mapping to improve laser lithotripsy for the treatment of kidney stones
Unmet Need The prevalence of kidney stones is on the rise, having increased from approximately 4% in the 1970s to nearly 10% today. Approximately 1 in 10 of Americans will experience a kidney stone in…
Method to produce durable synthetic rubbers that exhibit strain-induced crystallization (SIC) at ambient temperature
Unmet Need Polybutadiene is a synthetic rubber with high elasticity, resistance to wear, and robust ability to return to its original shape following deformation. These desirable characteristics have led to widespread use within manufacturing, namely…
Next-Generation Protein Linkers: Enhancing Stability and Targeting in Bioengineered Therapeutics
Unmet Need In protein bioengineering, stable and effective fusion proteins are crucial for therapeutic and diagnostic applications. However, current protein linkers often fail to maintain the stability, bioactivity, and targeted functionality needed, leading to limitations…