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Database of PET Images positive for Cardiac Sarcoidosis
Description The Clinical Database consists of PET scan images for 4 patients (FDG+Ammonia PET) only who have been identified as positive for cardiac sarcoidosis collected, annotated and compiled by DUKE and subject to Duke University…
Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism
Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…
Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network
Unmet Need Extreme ultraviolet (EUV) lithography is a patterning method that is at the forefront of semiconductor fabrication technology. EUV lithography uses wavelengths of light that are as small as 13 nm to produce incredibly…
Automated Method for De-Identifying Digital Imaging and Communications in Medicine Meta-Data and Burned-in Pixel Text
Unmet Need Clinical data that is organized and contains detailed patient information is critical for effectively treating high volumes of patients. One such form of clinical data includes medical images like magnetic resonance imaging (MRI),…
Type I CRISPR-Cascade: precise gene modulation platform for human cell applications
Unmet Need The gene editing sector has experienced a transformative surge in technological advancements with the emergence of CRISPR-Cas systems. These systems offer unprecedented capability to modify and modulate genetic sequences, proving instrumental from fundamental…
A novel non-addictive method for treating neuropathic pain associated with cancer
Unmet Need In the US alone, close to 1.9 million new cases of cancer are diagnosed each year and 44.5% of these patients will experience chronic pain. This type of chronic pain, called neuropathic pain,…
Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment
Unmet Need Breast cancer is the most common non-skin cancer in women in the United States, accounting for 1 in 3 of all new female cancers each year. Breast conserving surgery is a common treatment…
Holistic streamlined surgery patient perioperative risk assessment tool
Unmet Need Surgery poses major burdens for hospitals and patients. As of 2023, there are 6,129 hospitals in the United States performing a staggering 50 million surgeries each year. Despite the increased scrutiny on the…
A quantitative tool for real-time monitoring of cells cultured in a hollow fiber bioreactor
Unmet Need With the rise of cell therapies such as CAR-T cells for cancer and potentially autoimmune diseases, the methods of manufacturing cells in an efficient and safe manner are being studied and optimized constantly.…
Clinically-Linked ECG and Arrhythmia Repository (CLEAR)
Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…
Bacterial voltage gated ion channels for cardiac reprogramming
Unmet Need Untreated cardiovascular disease (CVD) can lead to irreversible heart damage. This occurs when ischemia — inadequate blood flow — leads to the death of heart muscle fibers that conduct electrical impulses. Consequently, scar…
A spatial coherence filtering method to increase resolution in color-flow ultrasound imaging
Unmet Need Color-flow ultrasound imaging is a technique that allows for visualization of blood flow within tissues and is frequently used to diagnose cardiovascular abnormalities, guide needle biopsies, examine tumor vascularity, and measure blood flow…