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Complete in vivo Protein Lipidation through Dynamic Metabolic Control of Acyl-CoA Biosynthesis
Unmet Need Protein therapeutics and biologics are becoming more common in healthcare. However, these molecules often struggle to cross epithelial barriers or cause immune reactions, necessitating either injection or direct site administration to be effective.…
Non-invasive method to predict rates of post-operative cognitive problems
Unmet Need Older adults are at a higher risk of cognitive dysfunction after surgery, with postoperative delirium (POD) being the most common disorder. POD is characterized by inattentiveness and is seen in 70-80% of intensive…
Automated drug diversion surveillance software
Unmet Need Drug diversion is a prevalent issue, among medical professionals. In addition to contributing to the opioid epidemic and causing infection outbreaks, drug diversion costs a yearly $70 billion within the healthcare industry alone.…
Database of PET Images positive for Cardiac Sarcoidosis
Description The Clinical Database consists of PET scan images for 4 patients (FDG+Ammonia PET) only who have been identified as positive for cardiac sarcoidosis collected, annotated and compiled by DUKE and subject to Duke University…
Biomarkers and novel targets for metabolic disease leveraging branched-chain amino acid metabolism
Unmet Need 1 in 3 adults in the United States have a form of metabolic dysregulation, including diabetes, insulin resistance, obesity, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). While these metabolic diseases range…
Modeling an extreme ultraviolet lithography mask by a deep fully convolutional network
Unmet Need Extreme ultraviolet (EUV) lithography is a patterning method that is at the forefront of semiconductor fabrication technology. EUV lithography uses wavelengths of light that are as small as 13 nm to produce incredibly…
Type I CRISPR-Cascade: precise gene modulation platform for human cell applications
Unmet Need The gene editing sector has experienced a transformative surge in technological advancements with the emergence of CRISPR-Cas systems. These systems offer unprecedented capability to modify and modulate genetic sequences, proving instrumental from fundamental…
A novel non-addictive method for treating neuropathic pain associated with cancer
Unmet Need In the US alone, close to 1.9 million new cases of cancer are diagnosed each year and 44.5% of these patients will experience chronic pain. This type of chronic pain, called neuropathic pain,…
Rapid non-invasive optical assay system for intraoperative breast tumor margin assessment
Unmet Need Breast cancer is the most common non-skin cancer in women in the United States, accounting for 1 in 3 of all new female cancers each year. Breast conserving surgery is a common treatment…
Holistic streamlined surgery patient perioperative risk assessment tool
Unmet Need Surgery poses major burdens for hospitals and patients. As of 2023, there are 6,129 hospitals in the United States performing a staggering 50 million surgeries each year. Despite the increased scrutiny on the…
A quantitative tool for real-time monitoring of cells cultured in a hollow fiber bioreactor
Unmet Need With the rise of cell therapies such as CAR-T cells for cancer and potentially autoimmune diseases, the methods of manufacturing cells in an efficient and safe manner are being studied and optimized constantly.…
Clinically-Linked ECG and Arrhythmia Repository (CLEAR)
Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…