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Novel Method for Treating Steatosis-Associated Diseases

Novel Method for Treating Steatosis-Associated Diseases

Unmet Need Steatosis-associated diseases are marked by the infiltration of the liver with fatty acids. Liver steatosis occurs in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), as well as rare diseases such as…

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Surface acoustic wave based separation techniques

Surface acoustic wave based separation techniques

Value Proposition Complex biofluids such as blood, urine etc. contain a plethora of particles of interest that are of diagnostic and research interest. Examples of such particles may include exosomes, or Circulating Tumor Cells (CTC).…

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Digital acoustofluidics: contactless liquid handling device via acoustic streaming

Digital acoustofluidics: contactless liquid handling device via acoustic streaming

Value Proposition For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Digital microfluidics (DMF) pioneers an appealing solution for economical automation by programmable manipulation…

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Method to trap and transport small particles with acoustic forces

Method to trap and transport small particles with acoustic forces

Value Proposition Acoustic tweezers use ultrasound to create radiation force potential wells that enable precise and contact-free manipulation of physical and biological objects across a broad object size range. It is a fast-developing platform that…

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Acoustofluidic centrifuge for nanoparticle enrichment and separation

Acoustofluidic centrifuge for nanoparticle enrichment and separation

Unmet Need Nanoparticle manipulation is highly relevant to biomedical and biochemical fields, and the ability to perform nanoparticle concentration and separation has emerged as a critical need in various settings such as point-of-care diagnostics, bioassays,…

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Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation

Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation

Unmet Need Precise and selective manipulation of microscale particles and cells in liquid suspension (colloidal mixture) is a challenge in the fields of biomedicine and materials science. Current methods for the assembly of colloidal matter…

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Gene expression signature to predict sepsis mortality

Gene expression signature to predict sepsis mortality

Unmet Need Sepsis is responsible for half of the in-hospital deaths in the US. It is characterized by organ dysfunction resulting from an uncontrolled response to an infection. The standard treatment for sepsis includes source…

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Molecular Classifiers of Bacterial Infection

Molecular Classifiers of Bacterial Infection

Unmet Need Bacterial infections can lead to various outcomes, with septicemia posing significant morbidity and mortality risks for patients. Septicemia occurs when bacteria enter and spread through the bloodstream, triggering an extreme immune response in…

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Vectorial Fourier ptychography for high-resolution widefield polarization imaging in pathology and research

Vectorial Fourier ptychography for high-resolution widefield polarization imaging in pathology and research

Unmet Need In the United States, over 10,000 diagnostic imaging centers rely on microscopy for diagnostics, with 70-80% of healthcare decisions dependent on timely pathology-based tests, a demand that is expected to grow. Fourier ptychography…

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Chest Pain Assessment Tool (CPAT), a fast and convenient chest pain diagnosis decision aid software

Chest Pain Assessment Tool (CPAT), a fast and convenient chest pain diagnosis decision aid software

Unmet Need Heart disease is the leading cause of death in the US. More than 7 million people present annually to emergency departments with symptoms of chest pain. Nearly 2% are misdiagnosed as not having…

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GOPTICAS: Systems and methods for measurements of Gross Primary Production (GPP)

GOPTICAS: Systems and methods for measurements of Gross Primary Production (GPP)

Unmet Need Over geological timescales, nearly half of the world’s atmospheric oxygen (O2) has been generated in the ocean by marine organisms such as algae, plankton and seaweed. These organisms synthesize oxygen based off the…

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Identification and application of novel lipoglycodepsipeptide antibiotics

Identification and application of novel lipoglycodepsipeptide antibiotics

Unmet Need Antibiotic resistance (ABR) is a global public health concern. In 2019, an estimated five million deaths were attributed to antibiotic resistant pathogens. A recent study estimates that ABR could cause nearly ten million…

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