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A novel all-in-one AAV system for efficient epigenome editing in neurodegenerative diseases
Unmet Need Neurodegenerative diseases such as Alzheimer’s and Parkinson’s affect over 55 million people worldwide, with prevalence expected to double by 2050 due to aging populations. These conditions are progressive, debilitating, and currently have no…
Viral-mediated humanized mouse model for Parkinson’s disease
Unmet Need Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain and the accumulation of α-synuclein aggregates (Lewy bodies), leading to motor and cognitive impairments. PD…
Pancreatic Cancer Treatment Targeting the Piezo1/TRPV4 Axis
Unmet Need Pancreatic cancer remains one of the most lethal cancers, with a 5-year survival rate of only 5–10%. In the U.S. alone, an estimated 64,000 people will be diagnosed each year, with over 55,000…
A novel T-cell-based immunotherapy for brain cancer
Unmet Need Cancer immunotherapy represents a new paradigm in cancer treatment with the goal of harnessing the immune system to selectively attack a patient’s tumor. T-cell-based immunotherapies encompass chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes,…
Method to improve durability of polymer networks of crosslinked elastomers
Unmet Need The lifespan of polymer materials is limited by premature failure due to poor mechanical properties such as toughness. Increased polymer toughness enhances material performance by improving its ability to absorb stress before breaking,…
Targeted SNCA Downregulation for Parkinson’s and Synucleinopathies
Unmet Need Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting approximately 10 million people globally and 1 million in the U.S. The disease is characterized by involuntary movements such as tremors, stiffness,…
Targeted delivery of gene therapy for cardiac injury treatment
Unmet Need After experiencing a heart attack, the adult human heart has no capacity to regenerate lost or damaged cardiac myocytes. This results in severely reduced heart function and eventually heart failure. There are more…
Permanent blood pressure control through liver-directed gene editing
Unmet Need The World Health Organization estimates that high blood pressure (hypertension) results in approximately 9 million annual deaths worldwide. While current medications can lower blood pressure, they are limited by the need for lifelong…
Schenk Composer: A framework for algorithmic music generation
Unmet Need Music composition remains largely inaccessible to individuals without formal training in music theory, despite growing interest in AI-assisted creative tools. Existing AI-generated music solutions frequently produce results that are uninterpretable and unpredictable, offering…
High-speed 3D tomographic imaging using a camera array
Unmet Need Tomographic imaging has revolutionized both scientific research and clinical procedures. 3D tomographic imaging reveals information about a sample’s volume, depth, and internal structures, which cannot be obtained from 2D imaging alone. However, 3D…
GPR37 and GPR37L1 Agonists for Non-Addictive Pain Resolution in Inflammatory and Neuropathic Pain
Unmet Need Chronic pain remains a widespread clinical issue, with existing treatments primarily focused on symptom suppression rather than addressing the biological mechanisms driving pain persistence. Opioids and NSAIDs provide temporary relief but fail to…
PD-L1-Based Therapy for Non-Opioid Treatment of Chronic Pain
Unmet Need Chronic pain, including inflammatory, neuropathic, and cancer-related pain, remains difficult to manage without opioids, which pose risks of addiction and adverse side effects. Existing non-opioid treatments often fail to provide sufficient relief or…