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Methods to implement three-dimensional (3D) sensing depth cameras
Unmet Need Real-time high-resolution three-dimensional (3D) imaging is highly desirable in a wide range of fields including biomedical imaging, robotics, virtual/augmented reality, 3D printing, and autonomous vehicles. To accomplish 3D imaging, sensing depth cameras have…
Vibrational Radar Backscatter Communications
Unmet Need The advent of autonomous driving powered by computational detection and assessment of vehicle surroundings by things like vision and radar has shown a lot of promise for self-driving vehicles. However, these systems can…
A User-Customizable Modular Microplate Holder
Unmet Need Globally, laboratory accessories had an estimated market value of $504.7 million in 2020. Microplates and accessories represent 16% of this global market, which totals to $80.7 million. Manufacturers sell a variety of microplates…
Novel immune checkpoints for cancer immunotherapy with tumor infiltrating lymphocytes
Unmet Need Adoptive cell therapy (ACT), or cellular immunotherapy, uses immune cells to combat cancer. Since 2017, CAR-T therapies have been rapidly adopted for hematological malignancies. However, for treating solid tumors, which account for 90%…
Novel ligand to target KRas-related cancers
Unmet Need Cancer is a serious health issue characterized by the abnormal growth of cells that invade and destroy healthy tissue. Nearly one in five human cancers features KRAS mutations, making it one of the…
Method for the in vitro differentiation of human dendritic cells from hematopoietic stem cells for research and immunotherapy development
Unmet Need Dendritic cells (DCs) play a critical role in the adaptive immune response by capturing and presenting antigens to activate cytotoxic T-cells. As such, naturally occurring DCs are thought to have crucial antitumor activity…
Gene signature for prediction of acute rejection in kidney transplant
Unmet Need Kidney transplant is the best current treatment for kidney failure. The kidney is the most common organ to be transplanted, and in 2019 there were 23,405 kidney transplants in the United States. Unfortunately,…
FK520 analogs modified to increase fungal specificity with applications in antifungal therapy
Unmet Need Fungal infections are becoming more prevalent worldwide, with 150 million cases and 1.7 million fatalities reported in the last year alone. These are largely caused by multi-drug-resistant fungi, which makes treatment more challenging.…
The Air-X Syringe: using airway loss of resistance for safer cricothyroidotomies
Unmet Need Between 13-20 million tracheal intubations are performed in the US each year, including surgical and emergency intubations. When the upper airway is obstructed, a needle cricothyroidotomy can be used to insert a catheter…
Elastomer films with strain-induced color change to detect functional failures
Unmet Need Elastomers are polymer materials that can recover their original shape after being deformed. These materials, such as rubber or some plastics, are widely used in industrial and commercial applications in the automobile and…
Functionalized microfiber mesh for inflammation and thrombosis prevention
Unmet Need Trauma is a significant global health issue responsible for approximately 10% of deaths and over 15% of disabilities worldwide according to the World Health Organization. In addition to physical injuries, trauma-induced inflammation plays…
An organ chip model of the mammalian joint
Unmet Need Human movement relies on the function of cartilage-containing joints. In conditions such as osteoarthritis (OA), the cartilage within the joints becomes inflamed and degrades, leading to intense debilitating pain when bending joints. Despite…