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Real-time monitoring and intervention of specific behaviors by simultaneous recordings of multiple brain regions
Unmet Need There is a need for more effective and precise methods to predict and regulate neurological behaviors, such as aggression, in mammals. Current treatments and behavioral interventions often fail to accurately prevent the onset…
Precision Engineering of Neural Circuits via Designer Connexins for Long-Term Cellular Integration
Unmet Need Gap junctions are crucial for enabling the direct flow of ions and small molecules between cells, playing a significant role in synchronizing electrical activity in organs like the heart and brain. However, mutations…
Targeted Ablation and Replacement of Sertoli Cells for Infertility Treatment
Value Proposition Infertility impacts 10-15% of couples, with up to 50% of cases linked to the male partner. While the majority (30%) of male infertility cases are idiopathic—having no known cause or effective treatment—a smaller…
Novel TRPV4-Targeted Therapy for Arrhythmic Cardiomyopathy
Unmet Need Arrhythmic cardiomyopathy (ACM) is a life-threatening condition characterized by fatty-fibrotic remodeling of the heart muscle, leading to arrhythmias, heart failure, and sudden cardiac death. While 60% of ACM cases are linked to known…
Computer Aided Detection Tool for Difficult-to-Detect Brain Metastases
Unmet Need An estimated 20% of all cancer patients will develop brain metastases in their lifetime. These metastases are first diagnosed by neuroradiologists using CT, and more commonly, MR imaging. If a limited number of…
Optimized hard-decision decoding for generalized product codes in high-speed communication systems
Unmet Need Communication channels often introduce errors due to noise, leading to the need for robust error control mechanisms. While techniques like forward error correction (FEC) add redundant bits to detect and correct transmission errors,…
Depth-Resolved Spectroscopic Imaging System for Early Cancer Detection and Diagnosis
Unmet Need Colorectal and esophageal cancers rank among the leading causes of cancer deaths in the United States. Early detection through screening is key to reducing mortality rates. Current screening methods, like colonoscopy for colorectal…
Automated cell membrane tension controller for studying mechanotransduction
Unmet Need Force-gated ion channels embedded in the cell membrane are central to mechanotransduction – the process by which mechanical forces are converted into electrochemical signals that regulate cellular behaviors such as motility, adhesion, and…
A predictive model for early detection of psychiatric risk in adolescents
Unmet Need According to the World Health Organization, nearly 15% of adolescents (10 to 19-year-olds) experience a mental health condition, many of which remain undiagnosed and untreated. Since the beginning of the COVID-19 pandemic, the…
SUMOylation as a therapeutic target in inflammatory bowel diseases and sepsis
Unmet Need Inflammatory Bowel Disease (IBD) affects between 2.4 – 3.1 million people in the USA alone, with significant risks of complications such as sepsis. Chronic inflammation from IBD results in severe intestinal tissue damage,…
Temporally Dependent Iterative Expansion (TEDIE), a novel algorithm that accurately identifies seizure-causing epileptic zones in the brain
Unmet Need Epilepsy is one of the most common neurological diseases in the world. As of 2023, approximately 50 million people live with epilepsy globally, and for these patients, premature death is up to 3…
A simple blood test that can predict heart failure earlier than current methods
Unmet Need Heart failure is the leading cause of morbidity and mortality in the developed world. Approximately 50% of the US population over the age of 45 is expected to have preclinical heart failure, and…