The combination of bupropion (Wellbutrin, Wellbutrin-SR, Zyban) and zonisamide (Zonegran) can be an effective weight loss and weight maintenance treatment for obese patients.

Technology

The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism.