The combination of bupropion (Wellbutrin, Wellbutrin-SR, Zyban) and zonisamide (Zonegran) can be an effective weight loss and weight maintenance treatment for obese patients.


The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism.

Duke File (IDF) Number



  • Gadde, Kishore
  • Krishnan, K. Ranga

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School of Medicine (SOM)