Skip to main content
Home Technologies Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization

Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization

Technology

The inventors have developed a strategy for purification of post-translationally modified peptides or proteins, and the identification of the various modifications. The methodology involves solid-phase immobilization of cysteine/thiol groups using mixed disulfides of resin-bound alkyl and aryl thiols. The method was utilized for the analysis of numerous cellular cysteine-modification including S-nitrosylation and S-palmitoylation.

Advantages

  • Efficient solid-phase immobilization of cysteine residues
  • Considerably more reactive than other commercially available resins

Have Questions?

Please contact us or subscribe for more opportunities

Stay in Touch with Us