Shank3 knockout mice as a model for autism
The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated with autism spectrum disorder.
Duke File (IDF) Number
T-003674
Inventor(s)
- Feng, Guoping
- Feliciano, Catia
- Fu, Zhanyan
- Peca Sivestre, Joao
- Ting, Jonathan
- Wang, Wenting
- Wells, Michael
For more information please contact
- Krishnan, Shweta
- 919-681-7541
- shweta.krishnan@duke.edu
College
School of Medicine (SOM)