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Home Technologies Shank3 knockout mice as a model for autism

Shank3 knockout mice as a model for autism

The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated with autism spectrum disorder.

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