Shank3 knockout mice as a model for autism

The Shank3B- knockout allele has a neo cassette replacing the PDZ domain (exons 13-16) of the Shank3 gene, resulting altered expression of the Shank3b isoform. These mice may be useful for studying behavioral abnormalities associated with autism spectrum disorder.

Duke File (IDF) Number



  • Feng, Guoping
  • Feliciano, Catia
  • Fu, Zhanyan
  • Peca Sivestre, Joao
  • Ting, Jonathan
  • Wang, Wenting
  • Wells, Michael

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School of Medicine (SOM)