A cDNA sequence encoding the ATX protein (Human ATX cDNA)

Value Proposition

ATX is an active protein kinase that plays a role in cellular stress responses, and defects in ATX also play a role in the development of cancer and other proliferative disorders. Thus, small molecule inhibitors of ATX could have therapeutic effects in certain human diseases, including cancer and autoimmunity. To develop these new therapies, tools to manipulate and produce the protein are needed.


This invention is a cDNA sequence encoding the ATX protein

Other Applications

The cDNA sequence could be used to prepare probes and antibodies to detect expression of the ATX mRNA and protein in various human tissues (normal or diseased)


  • This ATX cDNA clone represents a novel gene product
  • The cDNA allows for the expression of recombinant protein in various types of host cells
  • Production of recombinant ATX protein could be used in the development of an assay leading to screen for small molecule inhibitors of ATX kinase activity

Duke File (IDF) Number



  • Abraham, Robert
  • Brumbaugh, Kathryn
  • Otterness, Diane


    • Patent Number: 7,166,716
    • Title: ATM Related Kinase ATX, Nucleic Acids Encoding Same and Methods of Use
    • Country: United States of America

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School of Medicine (SOM)