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Intravesical UTI vaccine to induce bacteria-eradicating immune responses in the bladder
Unmet Need Urinary tract infections (UTI) are typically caused by uropathogenic E. coli (UPEC) that proliferate in urine and infect the urethra and bladder epithelial cells. UTIs represent the second most common bacterial infection in…
Platform for generating a seasonal vaccine for both influenza and coronaviruses
Unmet Need Similar to the flu vaccine, the need for seasonal post-immunization boosting to offer protection following COVID-19 vaccines remains possible. However, more than 8 percent of people who received a first dose of Pfizer…
Synthetic peptide adjuvants for mucosally-administered vaccines
Provided herein are peptides that have activity as mast cell activating proteins (MCAP), as well as compositions, adjuvant compositions, vaccines, and pharmaceutical formulations that include the peptides. Also provided are methods of using the peptides,…
Enhancing immune responses in a variety of applications with a lymph node targeting biodegradable nanoparticle
Unmet Need While vaccines have resulted in plummeting mortality rates in the human population over the last century, significant challenges remain for which current vaccine formulations fall short. For example, current influenza vaccines are unable…
Peptide materials for immunomodulation
Value Proposition Glatiramoids are biomaterials synthesized for use as immunomodulators. Specifically, they are polypeptide mixtures with randomized amino acid sequences. Glatiramoids are currently FDA approved for use in multiple sclerosis. They have also been explored…
Sublingual immunization using supramolecular peptide-polymer conjugate tablets
Value proposition Immunization with vaccines prevent illness, disability, and currently avert an estimated 2 to 3 million deaths every year. However, commonly-used vaccine technology platforms can be unpredictable, require a high manufacturing cost, and often…
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A therapeutic vaccine platform for treating influenza viruses
Value Proposition Influenza virus infections represent a substantial global burden on human health. Each year, it is estimated that influenza viruses cause up to 5 million severe infections globally, resulting in up to 645,000 mortalities.…
Alteration of dendritic cell metabolism to augment cancer vaccine efficacy
Value Proposition Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Immunotherapy is currently one of the treatment options for the 100,350 new melanomas that are estimated to be diagnosed in 2020 by…
Rapid immunoassay to detect anti-EGFRviii levels to evaluate vaccine efficacy
Value Proposition Tumor-specific molecules offer the possibility of targeted cancer therapy using monoclonal antibodies (mAbs) specifically directed against the tumor-specific molecule. However, it has proven difficult to identify tumor-specific molecules. Overexpression of EGFR in human…
Replication competent bi- and tri-valent influenza viruses as vaccines
Value Proposition Influenza infection is a major public health concern, with an estimated 200,000 Americans hospitalized each year with flu or flu-related illness. The most effective method for flu prevention is vaccination, however, due to…
An adjuvant-free vaccine platform using self-assembling nanofibers
Value Proposition Vaccines have application for a wide range of human health conditions, including the treatment of pathogenic diseases, cancer immunotherapy, and the suppression of autoimmune disorders. In order to stimulate the immune system to…