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Showing 7 matches for the following: Inventor: "Chilkoti, Ashutosh" ×
A class of biodegradable stealth polymers to improve drug delivery
Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…
A method for treating TRAIL-resistant cancers
Unmet Need Over the past twenty years, TNF-related apoptosis-inducing ligand (TRAIL) has been shown to kill a variety of human cancer cells in vitro and in vivo while remaining innocuous to healthy cells. Unfortunately, the…
A tumor-targeting delivery method for chemotherapeutics and other cargo
Unmet Need Delivery and therapeutic efficacy of small molecule imaging agents and chemotherapeutics are hampered by their short half-life, low solubility, non-selectivity to cancer cells, and toxic side effects. Small molecule chemotherapeutics, although in routine…
A nanoparticle drug delivery system for small molecule cancer drugs that binds endogenous albumin
Unmet Need Small molecule cancer drugs often suffer from poor systemic exposure, resulting from their low water solubility and short plasma half-life. Additionally, the off-target toxicity is the main challenge that undermines efficacy. Nanoparticle drug…
A rod-like nanoparticle drug delivery system for hydrophilic small molecules
Unmet Need New strategies to load small molecule drugs into nanoparticles are a powerful approach to improve the therapeutic efficacy of chemotherapeutics, and this has been a successful strategy for overcoming the limitations of poor…
A novel class of nanoparticles that can be recombinantly synthesized for drug delivery and other applications
Unmet Need Recombinant biopolymers are used for a diverse array of applications including drug delivery, tissue engineering, and clinical diagnostics. Peptide polymers are particularly attractive candidates for biomedical applications because of their biocompatibility, biodegradability, and…
Thermally-responsive elastin-like peptides for improving the efficacy of anticancer agents
Unmet Need The goal of chemotherapy is to deliver an anticancer agent, typically a small molecule, at a high dose to a tumor to kill rapidly proliferating tumor cells. Unfortunately, the maximum dose of many…