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Small molecules that can safely exploit copper as an antimicrobial
Value Proposition The fungal pathogen Cryptococcus neoformans can live in both plants and animals, but when inhaled by humans can disseminate from the lungs to the bloodstream and cause life-threatening systemic disease. The brain is…
Avicins and thioesterification to control protein function
Value Proposition Thioesterification agents can modify cysteine groups of signaling proteins in order to modify their activity. Pathologies that could benefit from such protein modifications, which modulate physiologic redox status, include atherosclerosis, cancer, bacterial infections,…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
New selective small molecule inhibitors for the treatment of pain and itch
Unmet Need In the United States, an estimated 50 million adults suffer from chronic pain and around 20 million adults suffer from high-impact chronic pain. Ongoing difficulty in safely treating pain has led to the…
Novel small molecule mast cell activator vaccine adjuvants
Value Proposition Mast cells (MCs) are innate immune cells highly prevalent in the dermal region of the skin and in the respiratory, gastrointestinal, and urinary tract mucosa. The strategic location at the host–environment interface and…
Novel therapeutic targets in the androgen receptor signaling pathway for prostate cancer
Unmet Need Prostate cancer is the most common malignancy in men. The most recent CDC data demonstrates that prostate cancer makes up 12.2% all new cancer cases in the U.S. at 207,430. Prostate cancers express…
A combination therapy for improving cancer therapy-induced senescence in tumor cells
Value Proposition Each year in the United States more than 200,000 women are diagnosed with invasive breast cancer. Despite diagnostic and treatment advances, breast cancer remains one of the leading causes of cancer deaths among…
Treating and reducing cardiac dysfunction with bisphosphonate compositions by increasing the phosphorylation of kinases in heart tissue
Value Proposition The prevalence of heart failure (“HF”) has grown to epidemic proportions as the population ages. HF may be caused by many forms of heart disease. Each of these disease processes can lead to…
Treating heart failure with bisphosphonate compositions
Value Proposition The prevalence of heart failure (“HF”) has grown to epidemic proportions as the population ages and as cardiologists have become more successful at reducing mortality from ischemic heart disease, the most common prelude…
Novel iron chelators that protect cells from oxidative stress
Unmet Need Metal ions play important roles in the proper functioning of any living organism, but pathologies can develop when metal homeostasis is disturbed. Too much loosely bound iron produces “reactive oxygen species” (ROS) that…
A rod-like nanoparticle drug delivery system for hydrophilic small molecules
Unmet Need New strategies to load small molecule drugs into nanoparticles are a powerful approach to improve the therapeutic efficacy of chemotherapeutics, and this has been a successful strategy for overcoming the limitations of poor…
A novel class of nanoparticles that can be recombinantly synthesized for drug delivery and other applications
Unmet Need Recombinant biopolymers are used for a diverse array of applications including drug delivery, tissue engineering, and clinical diagnostics. Peptide polymers are particularly attractive candidates for biomedical applications because of their biocompatibility, biodegradability, and…