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Clenbuterol Therapy for Amyotrophic Lateral Sclerosis
Unmet Need Amyotrophic lateral sclerosis (ALS) is a debilitating disease with progressive loss of muscle function and inevitable death usually in 3-5 years. There are currently two available therapies on the market which prolong life…
A class of biodegradable stealth polymers to improve drug delivery
Unmet Need Delivery of drugs or therapeutics such as small molecules, peptides, and proteins, in their native form, is limited by their poor stability, low solubility, and short in vivo circulation. These challenges in drug…
A method for treating TRAIL-resistant cancers
Unmet Need Over the past twenty years, TNF-related apoptosis-inducing ligand (TRAIL) has been shown to kill a variety of human cancer cells in vitro and in vivo while remaining innocuous to healthy cells. Unfortunately, the…
An implanted biomaterial to accelerate bone healing
Unmet Need A leading concept in regenerative medicine is transplantation of tissue-specific cells, often supported with biomaterials, to promote tissue repair. While this strategy has achieved some success, its broad clinical application is hindered by…
Small molecules that target RNA structures within the CoV genome
Unmet Need SARS-CoV-2 is the etiological agent of the COVID-19 respiratory disease, the largest scale respiratory virus pandemic the world has witnessed since the 1918 Spanish flu and that has claimed more than 1.4 million…
Method for treatment of dementia associated with Alzheimer’s disease and other neurodegenerative diseases
Unmet Need There are over 50 million people worldwide with dementia, with about 10 million new cases diagnosed every year. Though approximately 70% of dementia cases are associated with Alzheimer's disease patients, there is no…
A tumor-targeting delivery method for chemotherapeutics and other cargo
Unmet Need Delivery and therapeutic efficacy of small molecule imaging agents and chemotherapeutics are hampered by their short half-life, low solubility, non-selectivity to cancer cells, and toxic side effects. Small molecule chemotherapeutics, although in routine…
Iron-based photosensitizers to replace rare metals in solar energy applications
Unmet Need Unlike traditional solar cells composed of crystalline silicone, a new solar technology known as dye-sensitized solar cells (DSSCs), can be manufactured using roll-to-roll printing on transparent and flexible materials, thus providing a low-cost…
Photo-oxidants with comprehensive visible spectral coverage for energy conversion and catalysis
Unmet Need Photochemistry, or the use of light to promote chemical reactions, has only recently been adapted by pharmaceutical companies in the past 10 years due to the development of photoredox catalysts that utilize visible…
A bio-based method for producing adipic acid by using an enzyme to selectively convert 2-oxoadipate to (R)-2-hydroxyadipate
Unmet Need Adipic acid (1,4-butanedicarboxylic acid; COOH(CH2)4COOH), is among the most-produced chemicals worldwide, with approximately 2.5 billion kilograms synthesized annually and a global market of 8 billion USD. The most typical use for adipic acid…
Abl kinase inhibitors promote lung regeneration after pathogen and chemical-induced injury
Value Proposition Damage to the lung epithelium in response to pathogens is a major health problem worldwide. Parenchymal lung infections disrupt lung epithelial architecture and function by eliciting destruction of airway and alveolar cell populations.…
Targeting drugging molecules that promote cancer metastasis
Value Proposition Metastases, the spread of cancer cells to new areas of the body, are common and devastating complications of many kinds of cancers. For instance, bone metastasis occurs in 73% of advanced breast cancer…