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Transcriptional alterations during blood storage to monitor stored red cells and reduce storage-lesions
Unmet Need Currently, red blood cell (RBC) testing focuses on factors such as hemoglobin content, RBC count, blood typing, and antibody content. These tests, though comprehensive, do not measure the health and quality of RBCs.…
ECG rhythm database
Invention Summary Duke inventors have developed a database of digital 12- lead ECG samples that represent key rhythms of cardiac disorders. Each patient’s disorder was validated by a licensed and board-certified cardiovascular medicine physician to…
Tools for the rational design of improved odorant ligands and receptors
Unmet Need Our sense of smell, or olfaction, is integral to myriad aspects of everyday life, from our health and safety to our personal preferences. Yet the mechanisms behind olfaction are not well understood, leading…
Bio Layer Interferometry Probe (BLIP) for in-vivo analyte detection
Unmet Need Diagnostic tests play a critical role in the clinical diagnosis, management, and monitoring of disease. These tests are designed to analyze biological specimens to identify analytes of interest by employing highly specific and…
Electronic biosensor platform
A sensor comprising an electronic circuit electrically coupled to a type III-V semiconductor material, for example indium arsenide (InAs) and an antibody contacting the type III-V semiconductor material. The sensor produces measurable changes in the…
Wearable device for early detection of influenza and common cold
Unmet Need Approximately 10% of the US population is infected with influenza each year resulting in 3 to 5 million severe cases and up to 500,000 deaths. Early detection of influenza-like illness can limit the…
Novel biosensors made with non-fouling polymer materials
Unmet Need The advancement of personalized medicine and targeted therapies has led to growing interest in high-performance biosensors that detect the presence of target analytes in biological systems. Recently, with the commercial availability of semiconducting…
Portable device for imaging fluorescence microarray chips
Unmet Need Diagnostic assessment of protein biomarkers plays an essential role in modern medical practice, and its availability has a considerable impact on clinical evaluation and decision-making for human health and disease. Fluorescence is the…
A system for screening compounds that alter smell perception
Unmet Need Olfactory sensation profoundly influences a person’s quality of life. In addition to the aesthetic aspects of life associated with olfactory sensation, approximately 2 million Americans experience some type of olfactory dysfunction. Studies show…
A platform for detecting and discriminating odorant molecules in the vapor phase
Unmet Need Mammals are capable of detecting and recognizing a large number of odors. Olfactory receptors (ORs) play a crucial role in detecting and recognizing odorant molecules. There has been growing interest in elucidating the…
Integrated thin film silicon detectors for fluorescence sensing
Unmet Need Microfluidic chip-based systems allow for rapid and sensitive biochemical analyses of very small sample quantities. Due to the prevalence of optical equipment in laboratories, optical detection has become the most popular method for…
Miniaturized, ultra-high density, multichannel electrode array for long-term, intra-cranial neuronal recordings
Technology A high-density multichannel microwire electrode array is disclosed. The array can comprise a variable number of electrodes. A method of assembling the array is further disclosed. Additionally, a plurality of devices employing the array…