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Morphological multiparameter filtration and persistent homology in mitochondrial image analysis
Unmet Need Current mitochondrial network analysis tools require significant manual intervention, making them labor-intensive, subjective, and prone to variability. These limitations hinder the reproducibility and accuracy needed for studying complex mitochondrial morphologies in disease diagnostics,…
Void space and scaffold analysis of packed particles
Unmet Need Granular materials are used in countless contexts and are appealing for several applications in biomedical engineering, including injectable tissue mimics and 3-D bioprinting. Packed microgel particles form granular scaffolds, which have been used…
Harvis: an interactive virtual reality tool for modification and simulation of blood flow
Unmet Need Cardiovascular disease (CVD) is the largest underlying cause of mortality in the United States, causing one in every three deaths and costing an estimated $316 billion dollars a year. In recent years, computational…
Optical device for in vivo assessment of tissues
Value Proposition Fluorescence and diffuse reflectance spectroscopy in the ultraviolet-visible (UV-VIS) spectrum are increasingly being investigated for tissue characterization. These biological scatterers, absorbers, and fluorophores may be used to indicate the existence of certain diseases.…