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Targetable plasmid removal method
Unmet Need Bacterial pathogens represent a major challenge in the healthcare system. Hospitals harbor complex microbial communities where different bacterial pathogens can transfer undesirable plasmids that encode virulence and antibiotic resistance. This results in more…
Toolkit to edit any gene with universal CRISPR/Cas9 vectors
Unmet Need Genetic editing with the CRISPR/Cas9 system has quickly become ubiquitous in biotechnology research. One common application is studying proteins by editing the genes that encode them. Proteins have numerous functions, acting as receptors,…
Novel epigenome editors for multiplexed gene regulation
Unmet Need Epigenome editors activate or inhibit gene expression without modifying the underlying DNA sequence. Consequently, these editors can reversibly fine-tune gene expression without the risk of permanently altering the genome or off-target editing. Epigenome…
Method for increasing gene expression in mammalian cells from transfected plasmids
Unmet Need Mammalian cell-based protein expression systems enable the production of mammalian proteins in the most native structure and activity. Thus, they have been commonly used for producing antibodies and therapeutic proteins, and more recently,…
Detection and measurement of RNA modifications through targeted RNA editing
Value Proposition N6-methyladenosine, m6A, is the most frequent post-transcriptional modification in RNA that has been implicated in nearly every aspect of the RNA life cycle. Furthermore, proteins involved in the formation, removal, and recognition of…
A CRISPR-based system for modifying the length of 3’ untranslated regions (3’UTR) of an mRNA transcript that offers novel treatment strategies for prostate cancer and other diseases
Unmet Need Abnormal length changes in the 3’ untranslated region (3’UTR) of mRNAs are associated with many diseases such as systemic lupus erythematosus, α-thalassemia, facioscapulohumeral muscular dystrophy, and cancer. While existing technologies can manipulate expression…
A technique that promotes the stringent control of gene expression within specific cell types
Unmet Need A major challenge of gene therapy is to target only the intended cell- and/or tissue-type. For this reason, many gene therapies are delivered using adeno-associated virus (AAV) vectors with gene-specific promoters; however, off-target…
p3.1-64A-MART-A27L
The plasmid is used for in vitro transcription of RNA encoding the Melan A/ MART-1 human melanoma antigen with an alanine to leucine mutation at the 27th amino acid of the protein.
An expressible antidepressant-sensitive serotonin transporter
Value Proposition Serotonin-targeting antidepressants are now prescribed for a wide spectrum of disorders, including obsessive-compulsive disorder, depression, as well as eating, sleep, and panic disorders. Next generation therapeutic strategies to combat these disorders, and to…
A cDNA sequence encoding the ATX protein (Human ATX cDNA)
Value Proposition ATX is an active protein kinase that plays a role in cellular stress responses, and defects in ATX also play a role in the development of cancer and other proliferative disorders. Thus, small…
Human A1 adrenergic receptor genes
Value Proposition Alpha 1-Adrenergic receptors (alpha 1ARs) are virtually ubiquitous in human tissues and play roles in several important physiological functions such as smooth muscle contraction, glycogenolysis, and myocardial inotropy. Alpha blockers in current clinical…
A plasmid which overproduces the Tet(M) resistance protein (pSH52)
Value Proposition Bacterial resistance to current therapies remains a clinical challenge. For example, numerous enterococcal, staphylococcal, and streptococcal bacterial species are known to exhibit resistance to potent antibacterial tetracycline through upregulation of a ribosomal protection…