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A plate assay for in situ imaging of microbial growth in biofilms

A plate assay for in situ imaging of microbial growth in biofilms

Unmet Need As the study of antimicrobial-resistant biofilms becomes increasingly relevant, there is a need for a microplate assay that allows for continuous monitoring of biofilm formation by confocal laser scanning microscopy (CLSM). Microplate assays…

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Portable mass spectrometer with high sensitivity and resolution

Portable mass spectrometer with high sensitivity and resolution

Unmet Need Mass spectrometry is a method of particle composition analysis. Traditionally, mass spectrometers are large devices with high energy requirements, restricting them to high-resource laboratory settings. Mass spectrometry can be used for isotopic analysis…

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A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts

A robust and sensitive assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts

Unmet Need Cis-regulatory elements (cREs) of the genome are non-coding regions that play essential roles in regulating gene expression in development and disease. Importantly, these regions are characterized by the presence of “open” chromatin and…

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Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation

Harmonic acoustofluidics for non-contact, dynamic, selective (HANDS) particle manipulation

Unmet Need Precise and selective manipulation of microscale particles and cells in liquid suspension (colloidal mixture) is a challenge in the fields of biomedicine and materials science. Current methods for the assembly of colloidal matter…

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Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization

Solid-Phase Alkyl Aryl Mixed Disulfides for Highly Efficient Cysteine/Thiol Immobilization

Technology The inventors have developed a strategy for purification of post-translationally modified peptides or proteins, and the identification of the various modifications. The methodology involves solid-phase immobilization of cysteine/thiol groups using mixed disulfides of resin-bound…

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A fluorescent probe for monitoring beta-secretase activity in cells

A fluorescent probe for monitoring beta-secretase activity in cells

Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By…

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Two dimensional electrophoresis cassette

Two dimensional electrophoresis cassette

A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away…

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Test of Verbal Expression and Reasoning (TOVER)

Test of Verbal Expression and Reasoning (TOVER)

The TOVER is non-standardized assessment of expressive language in context and verbal reasoning. The 64 item test was specifically designed to assess language function in children and adults with Down syndrome across a broad range…

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