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Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor

Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…

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A platform for high-throughput quantification of gap junction hemichannel docking

A platform for high-throughput quantification of gap junction hemichannel docking

Unmet Need Gap junctions are transmembrane channels that facilitate for cell-cell communication. They play a crucial role in normal cellular physiology and their dysfunction or misregulation is associated with many human diseases. Gap junctions are…

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Method for increasing gene expression in mammalian cells from transfected plasmids

Method for increasing gene expression in mammalian cells from transfected plasmids

Unmet Need Mammalian cell-based protein expression systems enable the production of mammalian proteins in the most native structure and activity. Thus, they have been commonly used for producing antibodies and therapeutic proteins, and more recently,…

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A method for identifying sour-taste receptor ligands as well as compounds that modulate their activity

A method for identifying sour-taste receptor ligands as well as compounds that modulate their activity

Unmet Need The taste system is essential for feeding and survival as it helps humans evaluate the nutritional content in food. Every year, taste and smell dysfunctions affect more than 200,000 people, including those undergoing…

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DOV13 human ovarian adenocarcinoma cell line

DOV13 human ovarian adenocarcinoma cell line

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Cell line model of castration resistant prostate cancer

Cell line model of castration resistant prostate cancer

Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…

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Cell line model of enzalutamide resistant prostate cancer

Cell line model of enzalutamide resistant prostate cancer

Traditionally, AR drug discovery has used both ligand and AR structure-based design, seeking antagonists by classical ligand binding assays or cellular reporter assays that assess functional antagonism of androgen-dependent transcriptional activation. While these largely empirical…

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