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Novel TRPV4-Targeted Therapy for Arrhythmic Cardiomyopathy
Unmet Need Arrhythmic cardiomyopathy (ACM) is a life-threatening condition characterized by fatty-fibrotic remodeling of the heart muscle, leading to arrhythmias, heart failure, and sudden cardiac death. While 60% of ACM cases are linked to known…
Novel Method for Creating and Modifying Stable Cell Lines for Enhanced Proteomic Analysis
Unmet Need Characterizing the composition and function of protein complexes can facilitate the understanding of key cellular processes. Indeed, the global proteomics market was estimated to be USD 25.9 billion in 2021. However, the analysis…
Methods and compositions to sense m6A RNA modifications using a genetically encoded sensor
Unmet Need Gene expression is highly regulated through the addition of chemical modifications to RNA molecules. One such modification is methylation of adenosine residues to form m6A, a modified nucleotide which is found in thousands…
Cell lines for the overexpression of GPCRs
Technology Duke inventors have generated five novel cell lines that can be used for the stable overexpression of several GPCRs: HEK293-rATlaR (2pM/mg) HEK293-rATlaR (600fM/mg) NIH-3T3-Flag-Smo 1.1 NIH-3T3-Flag-Smo 1.7 HEK293-Flag-β2AR (2pM/mg, W9)
B-arrestin biosensor cell lines
Technology Duke inventors have created 14 novel biosensor cell lines that can be used for the detection of translocation events, generation of signaling messages, and protein-protein interactions within cells: U2OS-βarrestin2-YFP U2OS-βarrestin1-YFP 293-βarrestin2-YFP 293-βarrestin1-YFP NIH-3T3-Smo-GFP HEK293-rATlaR-CFP,…
Plasmids for the expression of B-arrestins and GRKs
Technology Duke inventors have generated 12 novel plasmids that can be used for the expression of β-arrestins and GRKs: pCDNA3-βarrestin1-Flag pCDNA3-βarrestin2-Flag pGEX-5G/LIC-βarrestin1 pGEX-5G/LIC-βarrestin2 pGEX-4T1-βarrestin1 C-terminus pGEX-4T1-βarrestin2 C-terminus pRK5-bGRK2 pRK5-bGRK3 pRK5-bGRK4 pRK5-hGRK5 pRK5-hGRK6 pRK5-hGRK26caax
Transgenic zebrafish to direct epicardial gene expression
Technology Duke inventors have generated a novel zebrafish model that allows researchers to study epicardial cells during embryonic heart development and myocardial regeneration. This zebrafish line is termed Tg(tcf21:CreER)pd42. Specifically, this transgenic model was created…
iPSC line to identify novel therapies for ARVC
Technology Duke inventors have developed a novel induced pluripotent stem cell (iPSC) line that contains a mutation that impacts the TAX1BP3 gene, which causes arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC). Specifically, the iPSCs were derived from…
Hamster a1B-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
Rat a1A-adrenergic receptor HeLa cell line
Technology Duke inventors have generated a human epithelial carcinoma (HeLa) cell line expressing the hamster α1B-adrenergic receptor.
An induced pluripotent stem cell model of Duchenne muscular dystrophy
Unmet Need Duchenne muscular dystrophy (DMD) is a rare genetic disease that causes the skeletal and heart muscles to weaken. Due to a mutation in dystrophin, an important protein involved in muscle structure, individuals with…
Cell line expressing chimeric Tie2 receptors
Technology Duke inventors have generated a cell line that expresses chimeric Tie2 receptors. Specifically, NIH 3T3 cells were infected with retroviruses containing a plasmid that encoded the extracellular and transmembrain domains of the c-fms receptor…